A combination of the modified catalytic core and conjugation of 3'-inverted deoxythymidine for a more efficient and nuclease-resistant 10-23 DNAzyme.

Li, Yang; Du, Shanshan; Jin, Hongwei; He, Junlin

Li, Yang; Du, Shanshan; Jin, Hongwei; He, Junlin.

Afiliación

Li Y; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
Du S; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
Jin H; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Science, Peking University, Beijing 100191, China.
He J; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. Electronic address: hejunlin@bmi.ac.cn.

Bioorg Med Chem Lett ; 62: 128633, 2022 04 15.

Article en En | MEDLINE | ID: mdl-35189319

Asunto(s)

ADN Catalítico; Dominio Catalítico; ADN; ADN Catalítico/química; Endonucleasas; ARN; Timidina

Palabras clave

10-23 DNAzyme; 3'-inverted 2'-deoxythymidine; Catalytic core; Enzymatic resistance; Observed rate constant

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN Catalítico Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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