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Modeling COVID-19 dynamic using a two-strain model with vaccination.
de León, Ugo Avila-Ponce; Avila-Vales, Eric; Huang, Kuan-Lin.
Afiliación
  • de León UA; Programa de Doctorado en Ciencias Biológicas, UNAM, Mexico City, Mexico.
  • Avila-Vales E; Facultad de Matemáticas, Universidad Autónoma de Yucatán. Anillo Periférico Norte. Tablaje Catastral 13615, C.P. 97119. Mérida, Yucatán.
  • Huang KL; Department of Genetics and Genomic Sciences. Center for Transformative Disease Modeling. Tisch Cancer Institute. Icahn Institute for Data Science and Genomic Technology. Icahn School of Medicine at Mount Sinai. New York. NY 10029. USA.
Chaos Solitons Fractals ; 157: 111927, 2022 Apr.
Article en En | MEDLINE | ID: mdl-35185299
Multiple strains of the SARS-CoV-2 have arisen and jointly influence the trajectory of the coronavirus disease (COVID-19) pandemic. However, current models rarely account for this multi-strain dynamics and their different transmission rate and response to vaccines. We propose a new mathematical model that accounts for two virus variants and the deployment of a vaccination program. To demonstrate utility, we applied the model to determine the control reproduction number ( R c ) and the per day infection, death and recovery rates of each strain in the US pandemic. The model dynamics predicted the rise of the alpha variant and shed light on potential impact of the delta variant in 2021. We obtained the minimum percentage of fully vaccinated individuals to reduce the spread of the variants in combination with other intervention strategies to deaccelerate the rise of a multi-strain pandemic.

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Chaos Solitons Fractals Año: 2022 Tipo del documento: Article País de afiliación: México Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Chaos Solitons Fractals Año: 2022 Tipo del documento: Article País de afiliación: México Pais de publicación: Reino Unido