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Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-Negative Activity.
Verma, Vishal A; Wang, Lan; Labadie, Sharada S; Liang, Jun; Sellers, Benjamin D; Wang, Jian; Dong, Liting; Wang, Qiuyue; Zhang, Shuang; Xu, Zhongya; Zhang, Yexia; Niu, Yanan; Wang, Xinxin; Wai, John; Koehler, Michael F T; Hu, Huiyong; Alexander, Mary Kate; Nishiyama, Mireille; Miu, Anh; Xu, Yiming; Pang, Jodie; Katakam, Anand K; Reichelt, Michael; Austin, Cary D; Ho, Hoangdung; Payandeh, Jian; Koth, Christopher M.
Afiliación
  • Verma VA; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Wang L; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Labadie SS; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Liang J; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Sellers BD; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Wang J; WuXi AppTec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, People's Republic of China.
  • Dong L; WuXi AppTec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, People's Republic of China.
  • Wang Q; WuXi AppTec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, People's Republic of China.
  • Zhang S; WuXi AppTec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, People's Republic of China.
  • Xu Z; WuXi AppTec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, People's Republic of China.
  • Zhang Y; WuXi AppTec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, People's Republic of China.
  • Niu Y; WuXi AppTec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, People's Republic of China.
  • Wang X; WuXi AppTec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, People's Republic of China.
  • Wai J; WuXi AppTec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, People's Republic of China.
  • Koehler MFT; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Hu H; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Alexander MK; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Nishiyama M; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Miu A; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Xu Y; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Pang J; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Katakam AK; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Reichelt M; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Austin CD; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Ho H; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Payandeh J; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Koth CM; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
J Med Chem ; 65(5): 4085-4120, 2022 03 10.
Article en En | MEDLINE | ID: mdl-35184554
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lipopolisacáridos / Escherichia coli Tipo de estudio: Diagnostic_studies / Risk_factors_studies / Screening_studies Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lipopolisacáridos / Escherichia coli Tipo de estudio: Diagnostic_studies / Risk_factors_studies / Screening_studies Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos