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The combination of nicotinamide mononucleotide and lycopene prevents cognitive impairment and attenuates oxidative damage in D-galactose induced aging models via Keap1-Nrf2 signaling.
Liu, Xuxin; Dilxat, Tursunay; Shi, Qiang; Qiu, Taoyu; Lin, Junping.
Afiliación
  • Liu X; Xinjiang Agricultural Vocational Technical College, Changji, Xinjiang, China. Electronic address: lxx529@hotmail.com.
  • Dilxat T; Xinjiang Agricultural Vocational Technical College, Changji, Xinjiang, China. Electronic address: dstm2006@126.com.
  • Shi Q; Xinjiang Agricultural Vocational Technical College, Changji, Xinjiang, China. Electronic address: 1736257186@qq.com.
  • Qiu T; Xinjiang Agricultural Vocational Technical College, Changji, Xinjiang, China. Electronic address: 1430306215@qq.com.
  • Lin J; Xinjiang Changji National High-Tech Industrial Development Zone, Changji, Xinjiang, China. Electronic address: 332739012@qq.com.
Gene ; 822: 146348, 2022 May 15.
Article en En | MEDLINE | ID: mdl-35183682
Aging is referred to progressive dysfunction of body organs, including the brain. This study aims to explore the anti-aging effect of combing nicotinamide mononucleotide (NMN) and lycopene (Lyco) (NMN + Lyco) on aging rats and senescent PC12 cells. Both in vivo and in vitro aging models were established using D-galactose (D-gal). The combination showed a trend to superiority over monotherapy in preventing aging in vivo and in vitro. Morris water maze test showed that NMN + Lyco effectively improved the ability of spatial location learning and memory of aging model rats. NMN + Lyco mitigated the oxidative stress of rat brains, livers, and PC12 cells by elevating the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), GSH, as well as total antioxidant capacity (T-AOC), and reducing malondialdehyde (MDA) content. CCK-8 assay, senescence-associated ß-galactosidase staining, and flow cytometer confirmed the cellular senescence of PC12 cells after exposing D-gal, and indicated the anti-senescence effect of NMN + Lyco in vitro. Moreover, NMN + Lyco effectively down-regulated the expressions of p53, p21, and p16 (senescence-related genes), and activated Keap1-Nrf2 signaling in both in vivo and in vitro aging models. In total, NMN + Lyco protected rats and PC12 cells from cognitive impairment and cellular senescence induced by D-gal, of which effects might be linked to the reduction of oxidative stress and the activation of Keap1-Nrf2 signaling.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Factor 2 Relacionado con NF-E2 / Disfunción Cognitiva / Proteína 1 Asociada A ECH Tipo Kelch / Licopeno / Galactosa / Mononucleótido de Nicotinamida Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Gene Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Factor 2 Relacionado con NF-E2 / Disfunción Cognitiva / Proteína 1 Asociada A ECH Tipo Kelch / Licopeno / Galactosa / Mononucleótido de Nicotinamida Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Gene Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos