ACTL6A deficiency induces apoptosis through impairing DNA replication and inhibiting the ATR-Chk1 signaling in glioblastoma cells.

Hu, Xiaosong; Pei, Dakun; Ci, Mingxin; Zhang, Guanghui; Li, Benqin; Wang, Jie; Shen, Yue; Zhai, Xuan; Liang, Ping; Cui, Hongjuan

Hu, Xiaosong; Pei, Dakun; Ci, Mingxin; Zhang, Guanghui; Li, Benqin; Wang, Jie; Shen, Yue; Zhai, Xuan; Liang, Ping; Cui, Hongjuan.

Afiliación

Hu X; State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, 400716, China.
Pei D; State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, 400716, China.
Ci M; State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, 400716, China.
Zhang G; State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, 400716, China.
Li B; Cancer Center, Medical Research Institute, Southwest University, Chongqing, 400716, China.
Wang J; Cancer Center, Medical Research Institute, Southwest University, Chongqing, 400716, China.
Shen Y; Cancer Center, Medical Research Institute, Southwest University, Chongqing, 400716, China.
Zhai X; Department of Neurosurgery, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China; Chongqing Key Laboratory of Pediatrics, Chongqing, 400010, China.
Liang P; Department of Neurosurgery, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China; Chongqing Key Laboratory of Pediatrics, Chongqing, 400010, China. Electronic address: liangping868@sina.com.
Cui H; State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, 400716, China; Cancer Center, Medical Research Institute, Southwest University, Chongqing, 400716, China. Electronic address: hcui@swu.edu.cn.

Biochem Biophys Res Commun ; 599: 148-155, 2022 04 09.

Article en En | MEDLINE | ID: mdl-35182941

Asunto(s)

Actinas/genética; Apoptosis/genética; Proteínas Cromosómicas no Histona/genética; Replicación del ADN; Proteínas de Unión al ADN/genética; Glioblastoma/genética; Glioblastoma/patología; Actinas/metabolismo; Proteínas de la Ataxia Telangiectasia Mutada/genética; Proteínas de la Ataxia Telangiectasia Mutada/metabolismo; Proteínas de Ciclo Celular/genética; Línea Celular Tumoral; Quinasa 1 Reguladora del Ciclo Celular (Checkpoint 1)/genética; Quinasa 1 Reguladora del Ciclo Celular (Checkpoint 1)/metabolismo; Proteínas Cromosómicas no Histona/metabolismo; Proteínas de Unión al ADN/metabolismo; Regulación Neoplásica de la Expresión Génica; Humanos; Transducción de Señal/fisiología

Palabras clave

ACTL6A; ATR-Chk1 pathway; DNA replication; Glioblastoma; MCM5

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Cromosómicas no Histona / Actinas / Apoptosis / Glioblastoma / Proteínas de Unión al ADN / Replicación del ADN Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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