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Generation and characterization of human-derived iPSC lines from one pair of dizygotic twins discordant for schizophrenia.
Ni, Peiyan; Wang, Huiyao; Cai, Jia; Ran, Junzhe; Jiang, Youhui; Zhao, Liansheng; Wei, Jinxue; Ni, Rongjun; Wang, Yingcheng; Ma, Xiaohong; Wang, Qiang; Guo, Wanjun; Li, Tao.
Afiliación
  • Ni P; The Psychiatric Laboratory and Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Wang H; The Psychiatric Laboratory and Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Cai J; The Psychiatric Laboratory and Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Ran J; The Psychiatric Laboratory and Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Jiang Y; The Psychiatric Laboratory and Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Zhao L; The Psychiatric Laboratory and Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Wei J; The Psychiatric Laboratory and Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Ni R; The Psychiatric Laboratory and Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Wang Y; The Psychiatric Laboratory and Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Ma X; The Psychiatric Laboratory and Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Wang Q; The Psychiatric Laboratory and Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Guo W; The Psychiatric Laboratory and Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Li T; Department of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou 310013, Zhejiang, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Science and Brain-machine Integra
Stem Cell Res ; 60: 102710, 2022 04.
Article en En | MEDLINE | ID: mdl-35182860
Schizophrenia (SCZ) is a debilitating neurodevelopmental disorder with a high heritability. In this study, peripheral blood mononuclear cells (PBMCs) were donated by a pair of dizygotic twins. The female was clinically diagnosed as SCZ by Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV) criteria, and her unaffected male sibling was healthy control. Induced pluripotent stem cells (iPSCs) were established using Episomal vectors carrying reprograming factors OCT4, SOX2, NANOG, LIN28, c-MYC, KLF4, and SV40LT. These lines with normal karyotype highly expressed pluripotency markers and are capable to differentiate into derivatives of three germ layers. Both lines are negative of mycoplasma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Células Madre Pluripotentes Inducidas Tipo de estudio: Guideline Límite: Female / Humans / Male Idioma: En Revista: Stem Cell Res Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Células Madre Pluripotentes Inducidas Tipo de estudio: Guideline Límite: Female / Humans / Male Idioma: En Revista: Stem Cell Res Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido