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Validity of the Web-Based, Self-Directed, NeuroCognitive Performance Test in Mild Cognitive Impairment.
Doraiswamy, P Murali; Goldberg, Terry E; Qian, Min; Linares, Alexandra R; Nwosu, Adaora; Nino, Izael; D'Antonio, Jessica; Phillips, Julia; Ndouli, Charlie; Hellegers, Caroline; Michael, Andrew M; Petrella, Jeffrey R; Andrews, Howard; Sneed, Joel; Devanand, Davangere P.
Afiliación
  • Doraiswamy PM; Neurocognitive Disorders Program, Department of Psychiatry, Duke University School of Medicine, Durham, NC, USA.
  • Goldberg TE; Duke Institute for Brain Sciences, Durham, NC, USA.
  • Qian M; Department of Psychiatry, Columbia University Medical Center, and the New York State Psychiatry Institute, New York, NY, USA.
  • Linares AR; Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, NY, USA.
  • Nwosu A; Neurocognitive Disorders Program, Department of Psychiatry, Duke University School of Medicine, Durham, NC, USA.
  • Nino I; Neurocognitive Disorders Program, Department of Psychiatry, Duke University School of Medicine, Durham, NC, USA.
  • D'Antonio J; Department of Psychiatry, Columbia University Medical Center, and the New York State Psychiatry Institute, New York, NY, USA.
  • Phillips J; Department of Psychiatry, Columbia University Medical Center, and the New York State Psychiatry Institute, New York, NY, USA.
  • Ndouli C; Department of Psychiatry, Columbia University Medical Center, and the New York State Psychiatry Institute, New York, NY, USA.
  • Hellegers C; Department of Psychiatry, Columbia University Medical Center, and the New York State Psychiatry Institute, New York, NY, USA.
  • Michael AM; Neurocognitive Disorders Program, Department of Psychiatry, Duke University School of Medicine, Durham, NC, USA.
  • Petrella JR; Duke Institute for Brain Sciences, Durham, NC, USA.
  • Andrews H; Department of Radiology, Duke University Medical Center, Durham, NC, USA.
  • Sneed J; Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, NY, USA.
  • Devanand DP; Department of Psychology, Queens College, City University of New York, Flushing, NY, USA.
J Alzheimers Dis ; 86(3): 1131-1136, 2022.
Article en En | MEDLINE | ID: mdl-35180109
BACKGROUND: Digital cognitive tests offer several potential advantages over established paper-pencil tests but have not yet been fully evaluated for the clinical evaluation of mild cognitive impairment. OBJECTIVE: The NeuroCognitive Performance Test (NCPT) is a web-based, self-directed, modular battery intended for repeated assessments of multiple cognitive domains. Our objective was to examine its relationship with the Alzheimer's Disease Assessment Scale-Cognition Subscale (ADAS-Cog) and Mini-Mental State Examination (MMSE) as well as with established paper-pencil tests of cognition and daily functioning in mild cognitive impairment (MCI). METHODS: We used Spearman correlations, regressions and principal components analysis followed by a factor analysis (varimax rotated) to examine our objectives. RESULTS: In MCI subjects, the NCPT composite is significantly correlated with both a composite measure of established tests (r = 0.78, p < 0.0001) as well as with the ADAS-Cog (r = -0.55, p < 0.0001). Both NCPT and paper-pencil test batteries had a similar factor structure that included a large "g" component with a high eigenvalue. The correlation for the analogous tests (e.g., Trails A and B, learning memory tests) were significant (p < 0.0001). Further, both the NCPT and established tests significantly (p < 0.0001) predicted the University of California San Diego Performance-Based Skills Assessment and Functional Activities Questionnaire, measures of daily functioning. CONCLUSION: The NCPT, a web-based, self-directed, computerized test, shows high concurrent validity with established tests and hence offers promise for use as a research or clinical tool in MCI. Despite limitations such as a relatively small sample, absence of control group and cross-sectional nature, these findings are consistent with the growing literature on the promise of self-directed, web-based cognitive assessments for MCI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Disfunción Cognitiva Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Disfunción Cognitiva Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos