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Impact of lobular versus ductal histology on overall survival in metastatic breast cancer: a French retrospective multicentre cohort study.
Dalenc, Florence; Lusque, Amélie; De La Motte Rouge, Thibault; Pistilli, Barbara; Brain, Etienne; Pasquier, David; Debled, Marc; Thery, Jean-Christophe; Gonçalves, Anthony; Desmoulins, Isabelle; Levy, Christelle; Uwer, Lionel; Ferrero, Jean-Marc; Eymard, Jean-Christophe; Mouret-Reynier, Marie-Ange; Patsouris, Anne; Frenel, Jean-Sébastien; Petit, Thierry; Chevrot, Michael; Bachelot, Thomas; Guiu, Séverine.
Afiliación
  • Dalenc F; Department of Medical Oncology, Institut Claudius Regaud-IUCT Oncopole, Toulouse, France.
  • Lusque A; Department of Biostatistics, Institut Claudius Regaud-IUCT Oncopole, Toulouse, France.
  • De La Motte Rouge T; Department of Medical Oncology, Centre Eugène Marquis, Rennes, France.
  • Pistilli B; Department of Cancer Medicine, Gustave Roussy, Villejuif, France.
  • Brain E; Department of Medical Oncology, Saint-Cloud and Paris, France.
  • Pasquier D; Department of Radiation Oncology, Centre Oscar Lambret, Lille, France.
  • Debled M; Department of Medical Oncology, Institut Bergonie, Bordeaux, France.
  • Thery JC; Department of Medical Oncology, Centre Henri Becquerel, Rouen, France.
  • Gonçalves A; Department of Medical Oncology, Institut Paoli-Calmettes, Marseille, France.
  • Desmoulins I; Department of Medical Oncology, Centre Georges François Leclerc, Dijon, France.
  • Levy C; Department of Medical Oncology, Centre François Baclesse, Caen, France.
  • Uwer L; Department of Medical Oncology, Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy, France.
  • Ferrero JM; Department of Medical Oncology, Centre Antoine Lacassagne, Nice, France.
  • Eymard JC; Department of Medical Oncology, Institut de Cancérologie Jean-Godinot, Reims, France.
  • Mouret-Reynier MA; Department of Medical Oncology, Centre Jean Perrin, Clermont Ferrand, France.
  • Patsouris A; Department of MedicalOncology, Institut de Cancérologie de L'Ouest-Paul Papin, Angers, France.
  • Frenel JS; Department of MedicalOncology, Institut de Cancérologie de L'Ouest-René Gauducheau, Nantes, France.
  • Petit T; Department of Medical Oncology, Centre Paul Strauss, Strasbourg, France.
  • Chevrot M; Department of Real Worl Data, Data Unit, Unicancer, Paris, France.
  • Bachelot T; Department of Medical Oncology, Centre Léon Bérard, Lyon, France.
  • Guiu S; Department of Medical Oncology, Institut Du Cancer de Montpellier, Montpellier, France. Electronic address: severine.guiu@icm.unicancer.fr.
Eur J Cancer ; 164: 70-79, 2022 03.
Article en En | MEDLINE | ID: mdl-35176614
BACKGROUND: The impact of the histological lobular subtype on overall survival (OS) in metastatic breast cancer (MBC) is still under debate, with very few data available. PATIENTS AND METHODS: Using the French national multicentre Epidemiological Strategy and Medico Economics [ESME]) data platform, the primary objective was to compare the OS of patients with invasive lobular carcinoma (ILC) versus invasive ductal carcinoma (IDC) MBC, with adjustment on the main prognostic factors using two approaches: multivariable analysis and matching with a propensity score. Secondary objectives were to compare first-line progression-free survival (PFS1) and describe patients and tumour characteristics. RESULTS: Of the 16,703 patients with MBC in the ESME database, 13,111 met all inclusion criteria for the present analysis. One-thousand eight-hundred and four (13.8%) patients had ILC and 11.307 (86.2%) IDC. In the multivariable analysis, patients with ILC had a worse OS [hazard ratio (HR): 1.31; 95%CI 1.20-1.42; p < 0.0001] and a worse PFS1 (HR: 1.15; 95%CI 1.07-1.22; p < 0.0001) as compared with those with IDC, independently of hormone receptor and HER2 status. Interestingly, OS was better (HR 0.79; 95% confidence interval [CI] 0.64-0.98; p = 0.0302), worse (HR: 1.17; 95%CI 1.08-1.27; p = 0.0001) or similar (HR: 0.88; 95%CI 0.67-1.15; p = 0.3455) in patients with ILC with triple-negative, hormone receptor-positive/HER2-negative and HER2-positive MBC, respectively, compared with patients with IDC. CONCLUSION: Lobular histology is an independent adverse prognostic factor among women with MBC. ILC MBC could be considered a specific entity. Dedicated prospective studies are needed to tailor the management of these patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Carcinoma Lobular / Carcinoma Ductal de Mama Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies Límite: Female / Humans / Male Idioma: En Revista: Eur J Cancer Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Carcinoma Lobular / Carcinoma Ductal de Mama Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies Límite: Female / Humans / Male Idioma: En Revista: Eur J Cancer Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido