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Results of ARI-0001 CART19 Cells in Patients With Chronic Lymphocytic Leukemia and Richter's Transformation.
Ortiz-Maldonado, Valentín; Frigola, Gerard; Español-Rego, Marta; Balagué, Olga; Martínez-Cibrián, Nuria; Magnano, Laura; Giné, Eva; Pascal, Mariona; Correa, Juan G; Martínez-Roca, Alexandra; Cid, Joan; Lozano, Miquel; Villamor, Neus; Benítez-Ribas, Daniel; Esteve, Jordi; López-Guillermo, Armando; Campo, Elías; Urbano-Ispizua, Álvaro; Juan, Manel; Delgado, Julio.
Afiliación
  • Ortiz-Maldonado V; Department of Hematology, Hospital Clínic de Barcelona, Barcelona, Spain.
  • Frigola G; Oncology and Hematology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
  • Español-Rego M; Department of Pathology, Hospital Clínic de Barcelona, Barcelona, Spain.
  • Balagué O; Department of Immunology, Hospital Clínic de Barcelona, Barcelona, Spain.
  • Martínez-Cibrián N; Oncology and Hematology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
  • Magnano L; Department of Pathology, Hospital Clínic de Barcelona, Barcelona, Spain.
  • Giné E; Department of Hematology, Hospital Clínic de Barcelona, Barcelona, Spain.
  • Pascal M; Department of Hematology, Hospital Clínic de Barcelona, Barcelona, Spain.
  • Correa JG; Oncology and Hematology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
  • Martínez-Roca A; Department of Hematology, Hospital Clínic de Barcelona, Barcelona, Spain.
  • Cid J; Oncology and Hematology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
  • Lozano M; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Barcelona, Spain.
  • Villamor N; Department of Immunology, Hospital Clínic de Barcelona, Barcelona, Spain.
  • Benítez-Ribas D; Department of Hematology, Hospital Clínic de Barcelona, Barcelona, Spain.
  • Esteve J; Department of Hematology, Hospital Clínic de Barcelona, Barcelona, Spain.
  • López-Guillermo A; Oncology and Hematology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
  • Campo E; Apheresis & Cell Therapy Unit, Department of Hemotherapy and Hemostasis, Hospital Clínic de Barcelona, Barcelona, Spain.
  • Urbano-Ispizua Á; Oncology and Hematology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
  • Juan M; Apheresis & Cell Therapy Unit, Department of Hemotherapy and Hemostasis, Hospital Clínic de Barcelona, Barcelona, Spain.
  • Delgado J; Department of Medicine, University of Barcelona, Barcelona, Spain.
Front Oncol ; 12: 828471, 2022.
Article en En | MEDLINE | ID: mdl-35174095
CART19 cells are emerging as an alternative therapy for patients with chronic lymphocytic leukemia (CLL). Here we report the outcome of nine consecutive patients with CLL treated with ARI-0001 CART19 cells, six of them with Richter's transformation (RT). One patient with RT never received therapy. The cytokine release syndrome rate was 87.5% (12.5% grade ≥3). Neurotoxicity was not observed in any patient. All patients experienced absolute B-cell aplasia, and seven (87.5%) responded to therapy. With a median follow-up of 5.6 months, two patients with RT experienced a CD19-negative relapse. In conclusion, ARI-0001 cell therapy was feasible, safe, and effective in patients with high-risk CLL or RT.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Oncol Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
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PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Oncol Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza