In vivo degradation of bacterial cell wall by the muralytic enzyme mutanolysin.
Infect Immun
; 52(2): 459-67, 1986 May.
Article
en En
| MEDLINE
| ID: mdl-3516873
The muralytic enzyme mutanolysin can act in vivo to eliminate chronic erosive arthritis induced in rats by polymers of peptidoglycan-polysaccharide isolated from group A streptococci (PG-APS). The amounts of PG-APS in the livers and spleens of rats treated with mutanolysin were significantly reduced compared with the amounts in control rats treated with phosphate-buffered saline. However, the amounts of PG-APS in the limbs of mutanolysin- and phosphate-buffered saline-treated rats were comparable. PG-APS polymers extracted from the livers, spleens, and limbs of mutanolysin-treated rats were extensively degraded, whereas PG-APS extracted from phosphate-buffered saline-treated rats had a high molecular weight. We propose that mutanolysin abrogates arthritis in rats by degrading PG-APS polymers to a size which is no longer able to induce chronic erosive arthritis, even though the polymers are still present in the limbs.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Endopeptidasas
/
Polisacáridos Bacterianos
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Artritis
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Artritis Experimental
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Peptidoglicano
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Pared Celular
Límite:
Animals
Idioma:
En
Revista:
Infect Immun
Año:
1986
Tipo del documento:
Article
Pais de publicación:
Estados Unidos