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Mesenchymal stem cells transfer mitochondria to allogeneic Tregs in an HLA-dependent manner improving their immunosuppressive activity.
Piekarska, Karolina; Urban-Wójciuk, Zuzanna; Kurkowiak, Malgorzta; Pelikant-Malecka, Iwona; Schumacher, Adriana; Sakowska, Justyna; Spodnik, Jan Henryk; Arcimowicz, Lukasz; Zielinska, Hanna; Tymoniuk, Boguslaw; Renkielska, Alicja; Siebert, Janusz; Slominska, Ewa; Trzonkowski, Piotr; Hupp, Ted; Marek-Trzonkowska, Natalia Maria.
Afiliación
  • Piekarska K; Department of Family Medicine, Medical University of Gdansk, Gdansk, Poland.
  • Urban-Wójciuk Z; Department of Medical Immunology, Medical University of Gdansk, Gdansk, Poland.
  • Kurkowiak M; International Centre for Cancer Vaccine Science, University of Gdansk, Gdansk, Poland.
  • Pelikant-Malecka I; International Centre for Cancer Vaccine Science, University of Gdansk, Gdansk, Poland.
  • Schumacher A; Department of Biochemistry, Medical University of Gdansk, Gdansk, Poland.
  • Sakowska J; Division of Medical Laboratory Diagnostics, Medical University of Gdansk, Gdansk, Poland.
  • Spodnik JH; Biobanking and Biomolecular Resources Research Infrastructure Poland (BBMRI.PL), Gdansk, Poland.
  • Arcimowicz L; Department of Pharmacology, Medical University of Gdansk, Gdansk, Poland.
  • Zielinska H; Department of Medical Immunology, Medical University of Gdansk, Gdansk, Poland.
  • Tymoniuk B; Department of Anatomy and Neurobiology, Medical University of Gdansk, Gdansk, Poland.
  • Renkielska A; International Centre for Cancer Vaccine Science, University of Gdansk, Gdansk, Poland.
  • Siebert J; Department of Medical Immunology, Medical University of Gdansk, Gdansk, Poland.
  • Slominska E; Department of Immunology and Allergy, Medical University of Lódz, Lódz, Poland.
  • Trzonkowski P; Department of Plastic Surgery, Medical University of Gdansk, Gdansk, Poland.
  • Hupp T; Department of Family Medicine, Medical University of Gdansk, Gdansk, Poland.
  • Marek-Trzonkowska NM; University Center for Cardiology, Gdansk, Poland.
Nat Commun ; 13(1): 856, 2022 02 14.
Article en En | MEDLINE | ID: mdl-35165293
Cell-based immunotherapies can provide safe and effective treatments for various disorders including autoimmunity, cancer, and excessive proinflammatory events in sepsis or viral infections. However, to achieve this goal there is a need for deeper understanding of mechanisms of the intercellular interactions. Regulatory T cells (Tregs) are a lymphocyte subset that maintain peripheral tolerance, whilst mesenchymal stem cells (MSCs) are multipotent nonhematopoietic progenitor cells. Despite coming from different origins, Tregs and MSCs share immunoregulatory properties that have been tested in clinical trials. Here we demonstrate how direct and indirect contact with allogenic MSCs improves Tregs' potential for accumulation of immunosuppressive adenosine and suppression of conventional T cell proliferation, making them more potent therapeutic tools. Our results also demonstrate that direct communication between Tregs and MSCs is based on transfer of active mitochondria and fragments of plasma membrane from MSCs to Tregs, an event that is HLA-dependent and associates with HLA-C and HLA-DRB1 eplet mismatch load between Treg and MSC donors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Comunicación Celular / Membrana Celular / Linfocitos T Reguladores / Células Madre Mesenquimatosas / Tolerancia Inmunológica / Mitocondrias Límite: Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2022 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Comunicación Celular / Membrana Celular / Linfocitos T Reguladores / Células Madre Mesenquimatosas / Tolerancia Inmunológica / Mitocondrias Límite: Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2022 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido