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Role of heart fatty acid binding protein in early detection of non ST-elevation myocardial infarct and its comparison with other cardiac markers.
Salman Habib, Syed Muhammad; Khan, Abdul Rasheed; Habib, Sultana; Ullah, Syed Zia; Sultana, Riffat; Tariq, Qazi Daniyal; Zardari, M Aslam; Imdad, Atiya.
Afiliación
  • Salman Habib SM; Department of Nuclear Medicine, Karachi Institute of Radiotherapy Nuclear Medicine, Karachi, Pakistan.
  • Khan AR; Department of Cardiology, Abbasi Shaheed Hospital and Karachi Institute of Heart Disease, Karachi, Pakistan.
  • Habib S; Department of Cardiology, Karachi Institute of Heart Disease, Karachi, Pakistan.
  • Ullah SZ; National Institute of Cardiovascular Diseases, Karachi, Pakistan.
  • Sultana R; Department of Cardiology, Karachi Institute of Heart Diseases, Karachi, Pakistan.
  • Tariq QD; MBBS Student, New York, America.
  • Zardari MA; Department of Adult Cardiology, National Institute of Cardiovascular Diseases, Karachi, Pakistan.
  • Imdad A; Department of Cardiology, Abbasi Shaheed Hospital, Karachi, Pakistan.
J Pak Med Assoc ; 71(1(B)): 233-238, 2021 Jan.
Article en En | MEDLINE | ID: mdl-35157655
OBJECTIVE: To determine the role of heart fatty acid-binding protein in early detection of non-ST-elevation myocardial infarction and its comparison with two other cardiac markers. METHODS: The cross-sectional study was conducted at Abbasi Shaheed Hospital, Karachi, from June 2012 to June 2014, and comprised patients presenting at the emergency department within two hours of chest pain and who were subsequently referred to the cardiology department with a provisional diagnosis of either unstable angina or non-ST-elevation myocardial infarction. Relevant history was taken on a specific proforma and electrocardiogram as well as routine investigations were done in the emergency department. Blood samples from the subjects were tested for the diagnosis of myocardial infarction through detection of heart fatty acid-binding protein, Troponin-I and Creatine kinase-myocardial band. Sensitivity and specificity of the three markers were calculated keeping coronary angiography as the gold standard. Data was analysed using SPSS 17. RESULTS: Out of 250 patients, 153(61.2%) were males. The overall mean age was 54.45±13.92 years. Sensitivity and specificity of heart fatty acid-binding protein were 80.6% and 78.5% (p<0.05), for Troponin-I, 37.7% and 75% (p>0.05), and for Creatine Kinase-myocardial band, 29.5% and 67.8% (p>0.05). CONCLUSIONS: Heart fatty acid-binding protein was found to be a good diagnostic tool for the detection of non-ST-elevation myocardial infarction.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infarto del Miocardio sin Elevación del ST / Infarto del Miocardio Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies / Screening_studies Límite: Adult / Aged / Humans / Male / Middle aged Idioma: En Revista: J Pak Med Assoc Año: 2021 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Pakistán
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infarto del Miocardio sin Elevación del ST / Infarto del Miocardio Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies / Screening_studies Límite: Adult / Aged / Humans / Male / Middle aged Idioma: En Revista: J Pak Med Assoc Año: 2021 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Pakistán