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Role of Bisphenol A in Autophagy Modulation: Understanding the Molecular Concepts and Therapeutic Options.
Sirasanagandla, Srinivasa Rao; Sofin, R G Sumesh; Al-Huseini, Isehaq; Das, Srijit.
Afiliación
  • Sirasanagandla SR; Department of Human and Clinical Anatomy, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Al-Khodh 123, Oman.
  • Sofin RGS; Department of Physics, College of Science, Sultan Qaboos University, Muscat, Al- Khodh 123, Oman.
  • Al-Huseini I; Department of Physiology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Al-Khodh 123, Oman.
  • Das S; Department of Human and Clinical Anatomy, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Al-Khodh 123, Oman.
Mini Rev Med Chem ; 22(17): 2213-2223, 2022.
Article en En | MEDLINE | ID: mdl-35156578
Bisphenol A (4,4'-isopropylidenediphenol) is an organic compound commonly used in plastic bottles, packaging containers, beverages, and resin industry. The adverse effects of bisphenol A in various systems of the body have been studied. Autophagy is a lysosomal degradation process that leads to the regeneration of new cells. The role of bisphenol A in autophagy modulation involved in the pathogenesis of diseases is still debatable. A few research studies have shown bisphenol Ainduced adverse effects to be associated with autophagy dysregulation, while a few have shown the activation of autophagy to be mediated by bisphenol A. Such contrasting views make the subject more interesting and debatable. In the present review, we discuss the different steps of autophagy, genes involved, and the effect of autophagy modulation by bisphenol A on different systems of the body. We also discuss the methods for monitoring autophagy and the roles of drugs, such as chloroquine, verteporfin, and rapamycin, in autophagy. A proper understanding of the role of bisphenol A in the modulation of autophagy may be important for future treatment and drug discovery.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autofagia / Compuestos de Bencidrilo Idioma: En Revista: Mini Rev Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Omán Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autofagia / Compuestos de Bencidrilo Idioma: En Revista: Mini Rev Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Omán Pais de publicación: Países Bajos