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A bis(pyrazolyl)methane derivative against clinical Staphylococcus aureus strains isolated from otitis externa.
Ocaña, Ana V; Aguilera-Correa, John J; Domínguez-Jurado, Elena; Pérez-Martínez, Francisco C; Pérez-Tanoira, Ramón; López-Carretero, Yaiza; Masiá-Mondejar, Jesús; Castro-Osma, José Antonio; Esteban, Jaime; Alonso-Moreno, Carlos; Molina-Alarcón, Milagros; Seguí, Pedro.
Afiliación
  • Ocaña AV; Instituto de Investigación en Discapacidades Neurológicas (IDINE) University of Castilla-La Mancha Albacete Spain.
  • Aguilera-Correa JJ; Clinical Microbiology Department IIS-Fundacion Jimenez Diaz-UAM Madrid Spain.
  • Domínguez-Jurado E; NanoCRIB Unit Centro Regional de Investigaciones Biomédicas Albacete Spain.
  • Pérez-Martínez FC; School of Pharmacy University of Castilla-La Mancha Albacete Spain.
  • Pérez-Tanoira R; Instituto de Investigación en Discapacidades Neurológicas (IDINE) University of Castilla-La Mancha Albacete Spain.
  • López-Carretero Y; Clinical Microbiology Department Hospital Universitario Príncipe de Asturias Madrid Spain.
  • Masiá-Mondejar J; Biomedicine y Biotechnology Department, School of Medicine University of Alcalá de Henares Alcalá de Henares Spain.
  • Castro-Osma JA; Clinical Microbiology Department IIS-Fundacion Jimenez Diaz-UAM Madrid Spain.
  • Esteban J; Instituto de Investigación en Discapacidades Neurológicas (IDINE) University of Castilla-La Mancha Albacete Spain.
  • Alonso-Moreno C; NanoCRIB Unit Centro Regional de Investigaciones Biomédicas Albacete Spain.
  • Molina-Alarcón M; School of Pharmacy University of Castilla-La Mancha Albacete Spain.
  • Seguí P; Clinical Microbiology Department IIS-Fundacion Jimenez Diaz-UAM Madrid Spain.
Laryngoscope Investig Otolaryngol ; 7(1): 283-290, 2022 Feb.
Article en En | MEDLINE | ID: mdl-35155809
OBJECTIVE: The purpose of this study was to evaluate the in vitro antibacterial effects of a p-Cymene-based bis(pyrazolyl)methane derivative (SC-19) to advance in developing alternative therapeutic compounds to fight against bacterial isolates from patients with otitis externa (OE). METHODS: Eighteen swab specimens were collected from patients aged over 18 years diagnosed with OE within at least 7 days of symptom onset, contaminated by only one bacterium type: Pseudomonas aeruginosa (n = 5); Staphylococcus aureus (n = 8); Klebsiella aerogenes (n = 2); Serratia marcescens (n = 1); Morganella morganii (n = 2). To appraise antibacterial activity, minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC), minimum biofilm inhibitory concentration (MBIC), and minimum biofilm eradication concentration (MBEC) assays were run at different SC-19 concentrations. RESULTS: When using SC-19, S. aureus strains showed less bacterial growth, but no bactericidal effect was observed. The MIC and MBC of SC-19 were 62.5 and 2000 µg/ml against S. aureus and were >2000 µg/ml against the other isolates obtained from OE, respectively. In addition, the MBICs and MBECs of SC-19 against S. aureus were 125 and >2000 µg/ml, respectively. CONCLUSION: Nowadays the acquired antibiotic resistance phenomenon has stimulated research into novel and more efficient therapeutic agents. Hence, we report that, helped by the structural diversity fostered herein by a range of bis(pyrazolyl)methane derivatives, SC-19 can be a promising alternative therapeutic option for treating OE caused by S. aureus given the observed effects on both planktonic state and biofilm. LEVEL OF EVIDENCE: IV.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Laryngoscope Investig Otolaryngol Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Laryngoscope Investig Otolaryngol Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos