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The Correlation Between Wall Shear Stress and Plaque Composition in Advanced Human Carotid Atherosclerosis.
Moerman, A M; Korteland, S; Dilba, K; van Gaalen, K; Poot, D H J; van Der Lugt, A; Verhagen, H J M; Wentzel, J J; van Der Steen, A F W; Gijsen, F J H; Van der Heiden, K.
Afiliación
  • Moerman AM; Department of Biomedical Engineering, Thorax Center, Erasmus MC, Rotterdam, Netherlands.
  • Korteland S; Department of Biomedical Engineering, Thorax Center, Erasmus MC, Rotterdam, Netherlands.
  • Dilba K; Department of Biomedical Engineering, Thorax Center, Erasmus MC, Rotterdam, Netherlands.
  • van Gaalen K; Department of Biomedical Engineering, Thorax Center, Erasmus MC, Rotterdam, Netherlands.
  • Poot DHJ; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands.
  • van Der Lugt A; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands.
  • Verhagen HJM; Department of Vascular Surgery, Erasmus MC, Rotterdam, Netherlands.
  • Wentzel JJ; Department of Biomedical Engineering, Thorax Center, Erasmus MC, Rotterdam, Netherlands.
  • van Der Steen AFW; Department of Biomedical Engineering, Thorax Center, Erasmus MC, Rotterdam, Netherlands.
  • Gijsen FJH; Department of Biomedical Engineering, Thorax Center, Erasmus MC, Rotterdam, Netherlands.
  • Van der Heiden K; Department of Biomedical Engineering, Delft University of Technology, Delft, Netherlands.
Front Bioeng Biotechnol ; 9: 828577, 2021.
Article en En | MEDLINE | ID: mdl-35155418
The role of wall shear stress (WSS) in atherosclerotic plaque development is evident, but the relation between WSS and plaque composition in advanced atherosclerosis, potentially resulting in plaque destabilization, is a topic of discussion. Using our previously developed image registration pipeline, we investigated the relation between two WSS metrics, time-averaged WSS (TAWSS) and the oscillatory shear index (OSI), and the local histologically determined plaque composition in a set of advanced human carotid plaques. Our dataset of 11 carotid endarterectomy samples yielded 87 histological cross-sections, which yielded 511 radial bins for analysis. Both TAWSS and OSI values were subdivided into patient-specific low, mid, and high tertiles. This cross-sectional study shows that necrotic core (NC) size and macrophage area are significantly larger in areas exposed to high TAWSS or low OSI. Local TAWSS and OSI tertile values were generally inversely related, as described in the literature, but other combinations were also found. Investigating the relation between plaque vulnerability features and different combinations of TAWSS and OSI tertile values revealed a significantly larger cap thickness in areas exposed to both low TAWSS and low OSI. In conclusion, our study confirmed previous findings, correlating high TAWSS to larger macrophage areas and necrotic core sizes. In addition, our study demonstrated new relations, correlating low OSI to larger macrophage areas, and a combination of low TAWSS and low OSI to larger cap thickness.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies Idioma: En Revista: Front Bioeng Biotechnol Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Suiza
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies Idioma: En Revista: Front Bioeng Biotechnol Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Suiza