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Inflammatory marker trajectories associated with frailty and ageing in a 20-year longitudinal study.
Samson, Leonard Daniël; Buisman, Anne-Marie; Ferreira, José A; Picavet, H Susan J; Verschuren, W M Monique; Boots, Annemieke Mh; Engelfriet, Peter.
Afiliación
  • Samson LD; National Institute of Public Health and the Environment Bilthoven The Netherlands.
  • Buisman AM; Department of Rheumatology and Clinical Immunology University of Groningen University Medical Center Groningen The Netherlands.
  • Ferreira JA; National Institute of Public Health and the Environment Bilthoven The Netherlands.
  • Picavet HSJ; National Institute of Public Health and the Environment Bilthoven The Netherlands.
  • Verschuren WMM; National Institute of Public Health and the Environment Bilthoven The Netherlands.
  • Boots AM; National Institute of Public Health and the Environment Bilthoven The Netherlands.
  • Engelfriet P; Julius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht University Utrecht The Netherlands.
Clin Transl Immunology ; 11(2): e1374, 2022.
Article en En | MEDLINE | ID: mdl-35154709
OBJECTIVE: The aim of this exploratory study was to investigate the development of low-grade inflammation during ageing and its relationship with frailty. METHODS: The trajectories of 18 inflammatory markers measured in blood samples, collected at 5-year intervals over a period of 20 years from 144 individuals aged 65-75 years at the study endpoint, were related to the degree of frailty later in life. RESULTS: IFN-γ-related markers and platelet activation markers were found to change in synchrony. Chronically elevated levels of IL-6 pathway markers, such as CRP and sIL-6R, were associated with more frailty, poorer lung function and reduced physical strength. Being overweight was a possible driver of these associations. More and stronger associations were detected in women, such as a relation between increasing sCD14 levels and frailty, indicating a possible role for monocyte overactivation. Multivariate prediction of frailty confirmed the main results, but predictive accuracy was low. CONCLUSION: In summary, we documented temporal changes in and between inflammatory markers in an ageing population over a period of 20 years, and related these to clinically relevant health outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Clin Transl Immunology Año: 2022 Tipo del documento: Article Pais de publicación: Australia
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Clin Transl Immunology Año: 2022 Tipo del documento: Article Pais de publicación: Australia