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Bentong ginger oleoresin mitigates liver injury and modulates gut microbiota in mouse with nonalcoholic fatty liver disease induced by high-fat diet.
Wang, Kunli; Li, Bei; Fu, Rao; Jiang, Zefang; Wen, Xin; Ni, Yuanying.
Afiliación
  • Wang K; College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, P. R. China.
  • Li B; National Engineering Research Center for Fruits and Vegetables Processing, Beijing, P. R. China.
  • Fu R; School of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, P. R. China.
  • Jiang Z; College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, P. R. China.
  • Wen X; National Engineering Research Center for Fruits and Vegetables Processing, Beijing, P. R. China.
  • Ni Y; College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, P. R. China.
J Food Sci ; 87(3): 1268-1281, 2022 Mar.
Article en En | MEDLINE | ID: mdl-35152443
The present study aimed to examine the protective effect of Bentong ginger oleoresin (BGO) on the occurrence of nonalcoholic fatty liver disease (NAFLD) and its underlying mechanism. In the present study, 14-week BGO treatment reduced the high-fat diet (HFD)-induced obesity. The serum total cholesterol (TC) was reduced from 4.76 ± 0.30 to 3.542 ± 0.49 mmol/L and fatty liver score decreased to the normal level (1.6 ± 0.55). BGO had antihypercholesterolemia activity, alleviated abnormal lipid metabolism, and improved liver fat accumulation. In addition, liver inflammatory cytokine tests and Western blotting analysis indicated that BGO might play an anti-inflammatory role by mediating the NF-κB signaling pathway. Moreover, BGO regulated the gut microbiota in NAFLD mice and finally mediated their benefits for the host, which might be associated with reduced abundance of Lachnospiraceae_NK4A136_group and Fournierella. BGO showed effective liver protection and regulation of gut microbiota for the HFD-induced NAFLD in obese mice. As a result, BGO may serve as an effective dietary supplement for the improvement of NAFLD-related metabolic diseases. PRACTICAL APPLICATION: This study provides a new way to improve the added value of Bentong ginger. It also provides certain experimental data on BGO as a kind of the functional food ingredient. The current work also provides new ideas for the improvement and treatment of NAFLD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Zingiber officinale / Enfermedad del Hígado Graso no Alcohólico / Microbioma Gastrointestinal Límite: Animals Idioma: En Revista: J Food Sci Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Zingiber officinale / Enfermedad del Hígado Graso no Alcohólico / Microbioma Gastrointestinal Límite: Animals Idioma: En Revista: J Food Sci Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos