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Altered cerebrovascular regulation in low birthweight swine.
Morton, Jude S; Patton, Breanna; Morse, Cameron J; El Karsh, Zeyad; Rodrigues, Lucas A; Mousseau, Darrell D; Ferguson, David P; Columbus, Daniel A; Weber, Lynn P; Olver, T Dylan.
Afiliación
  • Morton JS; Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
  • Patton B; Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
  • Morse CJ; Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
  • El Karsh Z; Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
  • Rodrigues LA; Department of Animal and Poultry Science, College of Agriculture and Bioresources, University of Saskatchewan, Saskatoon, SK, Canada; Prairie Swine Center, Inc., Saskatoon, SK, Canada.
  • Mousseau DD; Cell Signalling Laboratory, Department of Psychiatry, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
  • Ferguson DP; Department of Kinesiology, Michigan State University, East Lansing, MI, USA.
  • Columbus DA; Department of Animal and Poultry Science, College of Agriculture and Bioresources, University of Saskatchewan, Saskatoon, SK, Canada; Prairie Swine Center, Inc., Saskatoon, SK, Canada.
  • Weber LP; Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
  • Olver TD; Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada. Electronic address: dylan.olver@usask.ca.
Comp Biochem Physiol A Mol Integr Physiol ; 267: 111163, 2022 05.
Article en En | MEDLINE | ID: mdl-35151870
Full-term low birthweight (LBW) offspring exhibit peripheral vascular dysfunction in the postnatal period; however, whether such impairments extend to the cerebrovasculature remains to be elucidated. We used a swine model to test the hypothesis that LBW offspring would exhibit cerebrovascular dysfunction at later stages of life. Offspring from 14 sows were identified as normal birthweight (NBW) or LBW and were assessed at 28 (similar to end of infancy) and 56 (similar to childhood) days of age. LBW swine had lower absolute brain mass, but demonstrated evidence of brain sparing (increased brain mass scaled to body mass) at 56 days of age. The cerebral pulsatility index, based on transcranial Doppler, was increased in LBW swine. Moreover, arterial myography of isolated cerebral arteries revealed impaired vasoreactivity to bradykinin and reduced contribution of nitric oxide (NO) to vasorelaxation in the LBW swine. Immunoblotting demonstrated a lower ratio of phosphorylated-to-total endothelial NO synthase in LBW offspring. This impairment in NO signaling was greater at 28 vs. 56 days of age. Vasomotor responses to sodium nitroprusside (NO-donor) were unaltered, while Leu31, Pro34 neuropeptide Y-induced vasoconstriction was enhanced in LBW swine. Increases in total Y1 receptor protein content in the LBW group were not significant. In summary, LBW offspring displayed signs of cerebrovascular dysfunction at 28 and 56 days of age, evidenced by altered cerebral hemodynamics (reflective of increased impedance) coupled with endothelial dysfunction and altered vasomotor control. Overall, the data reveal that normal variance in birthweight of full-term offspring can influence cerebrovascular function later in life.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arterias / Vasodilatación Límite: Animals Idioma: En Revista: Comp Biochem Physiol A Mol Integr Physiol Asunto de la revista: BIOLOGIA MOLECULAR / FISIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arterias / Vasodilatación Límite: Animals Idioma: En Revista: Comp Biochem Physiol A Mol Integr Physiol Asunto de la revista: BIOLOGIA MOLECULAR / FISIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos