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Quantitative analysis of solid dosage forms of Losartan potassium by Raman spectroscopy.
Shafaq, Syeda; Irfan Majeed, Muhammad; Nawaz, Haq; Rashid, Nosheen; Akram, Maria; Yaqoob, Nimra; Tariq, Ayesha; Shakeel, Samra; Ul Haq, Anwar; Saleem, Mudassar; Zaman Nawaz, Muhammad; Zaki Abdul Bari, Rana.
Afiliación
  • Shafaq S; Department of Chemistry, University of Agriculture Faisalabad, Faisalabad 38000, Pakistan.
  • Irfan Majeed M; Department of Chemistry, University of Agriculture Faisalabad, Faisalabad 38000, Pakistan. Electronic address: irfan.majeed@uaf.edu.pk.
  • Nawaz H; Department of Chemistry, University of Agriculture Faisalabad, Faisalabad 38000, Pakistan. Electronic address: haqchemist@yahoo.com.
  • Rashid N; Department of Chemistry, University of Education, Faisalabad Campus, Faisalabad 38000, Pakistan.
  • Akram M; Department of Chemistry, University of Agriculture Faisalabad, Faisalabad 38000, Pakistan.
  • Yaqoob N; Department of Chemistry, University of Agriculture Faisalabad, Faisalabad 38000, Pakistan.
  • Tariq A; Department of Chemistry, University of Agriculture Faisalabad, Faisalabad 38000, Pakistan.
  • Shakeel S; Department of Chemistry, University of Agriculture Faisalabad, Faisalabad 38000, Pakistan.
  • Ul Haq A; Department of Chemistry, University of Agriculture Faisalabad, Faisalabad 38000, Pakistan.
  • Saleem M; Department of Chemistry, University of Agriculture Faisalabad, Faisalabad 38000, Pakistan.
  • Zaman Nawaz M; Department of Chemistry, University of Agriculture Faisalabad, Faisalabad 38000, Pakistan.
  • Zaki Abdul Bari R; Department of Chemistry, University of Agriculture Faisalabad, Faisalabad 38000, Pakistan.
Spectrochim Acta A Mol Biomol Spectrosc ; 272: 120996, 2022 May 05.
Article en En | MEDLINE | ID: mdl-35149485
Raman spectroscopy is an outstanding analytical tool increasingly utilized in the pharmaceutical field for the solid-state pharmaceutical drug analysis. In current study, the potential of Raman spectroscopy has been investigated for qualitative and quantitative analysis of solid dosage form of Losartan potassium. For this purpose, different solid dosage forms/concentrations of losartan potassium were prepared to compensate the commercially available pharmaceutical drug formulations and their Raman spectral data showed a gradual change in the specific Raman spectral features associated with the active pharmaceutical ingredient (API) of Losartan potassium as a function of change in the concentration. The Raman spectral data was analyzed by using Principal Component Analysis (PCA) for the classification of different spectral data sets of different concentrations of drug. Moreover, partial least square regression (PLSR) analysis was performed for monitoring the quantitative relation among different concentrations of Losartan potassium API and spectral data by constructing a predictive model. From the model, the value of root mean square error of calibration (RMSEC) and root mean square error of prediction (RMSEP) were observed to be 0.38 and 2.98 respectively and the value of goodness of fit was found to be 0.99. Furthermore, the quantity of unknown/blind sample of Losartan potassium formulation was also estimated by using PLSR model. From these results, it is demonstrated that Raman spectroscopy can be considered to be used for quick and reliable quantitative analysis of pharmaceutical solids.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espectrometría Raman / Losartán Tipo de estudio: Prognostic_studies / Qualitative_research Idioma: En Revista: Spectrochim Acta A Mol Biomol Spectrosc Asunto de la revista: BIOLOGIA MOLECULAR Año: 2022 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espectrometría Raman / Losartán Tipo de estudio: Prognostic_studies / Qualitative_research Idioma: En Revista: Spectrochim Acta A Mol Biomol Spectrosc Asunto de la revista: BIOLOGIA MOLECULAR Año: 2022 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Reino Unido