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Resveratrol Relaxes Human Gastric Smooth Muscles Through High Conductance Calcium-Activated Potassium Channel in a Nitric Oxide-independent Manner.
Modzelewska, Beata; Drygalski, Krzysztof; Hady, Hady Razak; Kielczewska, Aleksandra; Chomentowski, Andrzej; Korycinski, Krzysztof; Gluszynska, Paulina; Kleszczewski, Tomasz.
Afiliación
  • Modzelewska B; Department of Biophysics, Faculty of Medicine, Medical University of Bialystok, Bialystok, Poland.
  • Drygalski K; Department of Biophysics, Faculty of Medicine, Medical University of Bialystok, Bialystok, Poland.
  • Hady HR; Clinical Research Center, Medical University of Bialystok, Bialystok, Poland.
  • Kielczewska A; Clinical Department of General and Endocrine Surgery, Medical University of Bialystok, Bialystok, Poland.
  • Chomentowski A; Department of Biophysics, Faculty of Medicine, Medical University of Bialystok, Bialystok, Poland.
  • Korycinski K; Department of Biophysics, Faculty of Medicine, Medical University of Bialystok, Bialystok, Poland.
  • Gluszynska P; Department of Biophysics, Faculty of Medicine, Medical University of Bialystok, Bialystok, Poland.
  • Kleszczewski T; Clinical Department of General and Endocrine Surgery, Medical University of Bialystok, Bialystok, Poland.
Front Pharmacol ; 13: 823887, 2022.
Article en En | MEDLINE | ID: mdl-35145416
Resveratrol, as a polyphenolic compound that can be isolated from plants, and also a component of red wine has broad beneficial pharmacological properties. The aim was to investigate the role of nitric oxide and potassium channels in resveratrol-induced relaxation of human gastric smooth muscle. Gastric tissues were obtained from patients who underwent sleeve gastrectomy for severe obesity (n = 10 aged 21-48; BMI 48.21 ± 1.14). The mechanical activity from the muscle strips was detected under isometric conditions as the response to increasing concentrations of resveratrol before and after different pharmacological treatments. Resveratrol caused an observable, dose-dependent gastric muscle relaxation. The maximal response caused by the highest concentration of resveratrol was 83.49 ± 2.85% (p < 0.0001) of the control. Preincubation with L-NNA, L-NAME, or ODQ did not prevent the resveratrol-induced relaxation. Apamin, glibenclamide, 4AP or tamoxifen, did not inhibit the relaxing effect of resveratrol, as well. In turn, blocking BKCa by TEA, iberiotoxin, or charybdotoxin resulted in inhibition of resveratrol-induced relaxation (91.08 ± 2.07, p < 0.05; 95.60 ± 1.52, p < 0.01 and 89.58 ± 1.98, p < 0.05, respectively). This study provides the first observation that the relaxant effects of resveratrol in human gastric muscle strips occur directly through BKCa channels and independently of nitric oxide signaling pathways. Furthermore, there is considerable potential for further extensive clinical studies with resveratrol as an effective new drug or health supplement to treat gastrointestinal dyspepsia and other gastric hypermotility disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza