Amplification Artifact in SARS-CoV-2 Omicron Sequences Carrying P681R Mutation, New York, USA.

Heguy, Adriana; Dimartino, Dacia; Marier, Christian; Zappile, Paul; Guzman, Emily; Duerr, Ralf; Wang, Guiqing; Plitnick, Jonathan; Russell, Alexis; Lamson, Daryl M; St George, Kirsten

Heguy, Adriana; Dimartino, Dacia; Marier, Christian; Zappile, Paul; Guzman, Emily; Duerr, Ralf; Wang, Guiqing; Plitnick, Jonathan; Russell, Alexis; Lamson, Daryl M; St George, Kirsten.

Emerg Infect Dis ; 28(4): 881-883, 2022 04.

Article en En | MEDLINE | ID: mdl-35130474

RESUMEN

Of 379 severe acute respiratory syndrome coronavirus 2 samples collected in New York, USA, we detected 86 Omicron variant sequences containing Delta variant mutation P681R. Probable explanations were co-infection with 2 viruses or contamination/amplification artifact. Repeated library preparation with fewer cycles showed the P681R calls were artifactual. Unusual mutations should be interpreted with caution.

Asunto(s)

COVID-19; SARS-CoV-2; Artefactos; Humanos; Mutación; New York/epidemiología; SARS-CoV-2/genética

Palabras clave

2019 novel coronavirus disease; COVID-19; SARS-CoV-2; amplification artifact; coronavirus disease; genomics; respiratory infections; sequence analysis; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Límite: Humans País/Región como asunto: America do norte Idioma: En Revista: Emerg Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos

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