Involvement of the NF-&#954;B and PI3K/Akt/mTOR pathways in cell death triggered by stypoldione, an o-quinone isolated from the brown algae Stypopodium zonale.

Walter, Laura O; Maioral, Mariana F; Silva, Lisandra O; Speer, Douglas B; Campbell, Sanjay C; Gallimore, Winklet; Falkenberg, Miriam B; Santos-Silva, Maria Cláudia

Involvement of the NF-κB and PI3K/Akt/mTOR pathways in cell death triggered by stypoldione, an o-quinone isolated from the brown algae Stypopodium zonale.

Walter, Laura O; Maioral, Mariana F; Silva, Lisandra O; Speer, Douglas B; Campbell, Sanjay C; Gallimore, Winklet; Falkenberg, Miriam B; Santos-Silva, Maria Cláudia.

Afiliación

Walter LO; Experimental Oncology and Hemopathies Laboratory, Clinical Analysis Department, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Maioral MF; Post-Graduation Program in Pharmacy, Health Sciences Center, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Silva LO; Experimental Oncology and Hemopathies Laboratory, Clinical Analysis Department, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Speer DB; Post-Graduation Program in Pharmacy, Health Sciences Center, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Campbell SC; Experimental Oncology and Hemopathies Laboratory, Clinical Analysis Department, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Gallimore W; Post-Graduation Program in Pharmacy, Health Sciences Center, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Falkenberg MB; Experimental Oncology and Hemopathies Laboratory, Clinical Analysis Department, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Santos-Silva MC; Department of Chemistry, University of the West Indies, St. Andrew, Jamaica.

Environ Toxicol ; 37(6): 1297-1309, 2022 Jun.

Article en En | MEDLINE | ID: mdl-35128807

Asunto(s)

FN-kappa B; Phaeophyceae; Apoptosis; Leucocitos Mononucleares/metabolismo; FN-kappa B/metabolismo; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Quinonas/farmacología; Especies Reactivas de Oxígeno/metabolismo; Serina-Treonina Quinasas TOR/metabolismo

Palabras clave

NF-κB; ROS; apoptosis; multiple myeloma; quinone

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: FN-kappa B / Phaeophyceae Idioma: En Revista: Environ Toxicol Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos

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