Dynamic Multiscale Regulation of Perfusion Recovery in Experimental Peripheral Arterial Disease: A Mechanistic Computational Model.

Zhao, Chen; Heuslein, Joshua L; Zhang, Yu; Annex, Brian H; Popel, Aleksander S

Zhao, Chen; Heuslein, Joshua L; Zhang, Yu; Annex, Brian H; Popel, Aleksander S.

Afiliación

Zhao C; School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, China.
Heuslein JL; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Zhang Y; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia, USA.
Annex BH; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Popel AS; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia, USA.

JACC Basic Transl Sci ; 7(1): 28-50, 2022 Jan.

Article en En | MEDLINE | ID: mdl-35128207

Palabras clave

ARG1, arginase-1; EC, endothelial cell; HLI, hindlimb ischemia; HMGB1, high-mobility group box 1; HUVEC, human umbilical vein endothelial call; IFN, interferon; IL, interleukin; MLKL, mixed lineage kinase domain-like protein; PAD, peripheral arterial disease; RT-PCR, reverse transcriptase polymerase chain reaction; TLR4, Toll-like receptor 4; TNF, tumor necrosis factor; VEGF, vascular endothelial growth factor; VMP, virtual mouse population; hindlimb ischemia; macrophage polarization; mathematical modeling; necrosis/necroptosis; perfusion recovery; peripheral arterial disease; systems biology; virtual mouse population

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: JACC Basic Transl Sci Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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