Sex-Dependent Effect of Platelet Nitric Oxide: Production and Platelet Reactivity in Healthy Individuals.

Godwin, Matthew D; Aggarwal, Anu; Hilt, Zachary; Shah, Shalini; Gorski, Joshua; Cameron, Scott J

Sex-Dependent Effect of Platelet Nitric Oxide: Production and Platelet Reactivity in Healthy Individuals.

Godwin, Matthew D; Aggarwal, Anu; Hilt, Zachary; Shah, Shalini; Gorski, Joshua; Cameron, Scott J.

Afiliación

Godwin MD; Cleveland Clinic Lerner College of Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Aggarwal A; Cleveland Clinic Lerner College of Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Hilt Z; Department of Medicine, Aab Cardiovascular Research Center, University of Rochester School of Medicine, Rochester, New York, USA.
Shah S; Department of Medicine, Division of Cardiology, University of Rochester School of Medicine, Rochester, New York, USA.
Gorski J; Department of Medicine, Division of Cardiology, University of Rochester School of Medicine, Rochester, New York, USA.
Cameron SJ; Cleveland Clinic Lerner College of Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

JACC Basic Transl Sci ; 7(1): 14-25, 2022 Jan.

Article en En | MEDLINE | ID: mdl-35128205

RESUMEN

A nitrate-rich diet has many cardiovascular benefits, but the mechanism behind this is unclear. We hypothesized that the ingestion of nitrate augments nitrate to nitrite reduction, leading to nitric oxide (NO) production, which may suppress platelet reactivity. In a randomized, double-blinded, placebo-controlled study involving healthy individuals, ingestion of nitrate augmented saliva and plasma nitrite/nitrate concentration and enhanced platelet NO production disproportionately in women compared with men. The response of elevated platelet NO in men was increased platelet reactivity and the response of markedly elevated platelet NO in women slightly inhibited platelet reactivity.

Palabras clave

ADP, adenosine diphosphate; DAF-FM, 4-amino-5-methylamino-2Ê¹, 7Ê¹-difluorofluorescein diacetate; LTA, light transmission aggregometry; NO, nitric oxide; PAR1, protease-activated receptor 1; PKG, protein kinase G; VASP, vasodilator-stimulated phosphoprotein; aggregation; nitrate; nitric oxide; nitrite; plant; platelet; women

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: JACC Basic Transl Sci Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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