Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics.

Gao, Jian; Wu, Zhigui; Zhao, Mingxia; Zhang, Rui; Li, Manru; Sun, Dongdong; Cheng, Haibo; Qi, Xianjia; Shen, Yuxian; Xu, Qiang; Chen, Hongqi; Chen, Dijun; Sun, Yang

Gao, Jian; Wu, Zhigui; Zhao, Mingxia; Zhang, Rui; Li, Manru; Sun, Dongdong; Cheng, Haibo; Qi, Xianjia; Shen, Yuxian; Xu, Qiang; Chen, Hongqi; Chen, Dijun; Sun, Yang.

Afiliación

Gao J; State Key Laboratory of Pharmaceutical Biotechnology, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Life Sciences, Nanjing University, Nanjing 210023, China.
Wu Z; State Key Laboratory of Pharmaceutical Biotechnology, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Life Sciences, Nanjing University, Nanjing 210023, China.
Zhao M; State Key Laboratory of Pharmaceutical Biotechnology, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Life Sciences, Nanjing University, Nanjing 210023, China.
Zhang R; Biopharmaceutical Research Institute, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
Li M; Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, China.
Sun D; State Key Laboratory of Pharmaceutical Biotechnology, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Life Sciences, Nanjing University, Nanjing 210023, China.
Cheng H; The First Clinical College of Nanjing University of Chinese Medicine, Nanjing 210023, China.
Qi X; The First Clinical College of Nanjing University of Chinese Medicine, Nanjing 210023, China.
Shen Y; Shanghai XuRan Biotechnology Co., Ltd., Shanghai 201109, China.
Xu Q; Biopharmaceutical Research Institute, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
Chen H; State Key Laboratory of Pharmaceutical Biotechnology, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Life Sciences, Nanjing University, Nanjing 210023, China.
Chen D; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China.
Sun Y; Department of General Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.

Acta Pharm Sin B ; 12(1): 149-166, 2022 Jan.

Article en En | MEDLINE | ID: mdl-35127377

Palabras clave

APC, antigen-presenting cell; BTLA, B- and T-lymphocyte attenuator; CNVs, copy number variations; CRC, colorectal cancer; Colorectal cancer; DSBs, double-strand breaks; GSEA, gene set enrichment analysis; KRAS, Kirsten rat sarcoma viral oncogene homolog; MAPK, mitogen-activated kinase; MSI, microsatellite instability; MSS, microsatellite stable; Macrophage; PCA, principal component analysis; PD-1, programmed cell death 1; PTPN11; SHP099; STING; STING, stimulator of interferon genes; TME, tumor microenvironment; Tumor microenvironment; Type I interferon; scRNA-seq; scRNA-seq, single-cell RNA-sequencing; t-SNE, t-distributed stochastic neighbor embedding

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Acta Pharm Sin B Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos

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