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Understanding the function and regulation of Sox2 for its therapeutic potential in breast cancer.
Dey, Ankita; Kundu, Moumita; Das, Subhayan; Jena, Bikash Chandra; Mandal, Mahitosh.
Afiliación
  • Dey A; Cancer Biology Lab, School of Medical Science and Technology, Indian Institute of Technology Kharagpur (IIT Kharagpur), Kharagpur, West Bengal, India.. Electronic address: ankita_dey@kgpian.iitkgp.ac.in.
  • Kundu M; Cancer Biology Lab, School of Medical Science and Technology, Indian Institute of Technology Kharagpur (IIT Kharagpur), Kharagpur, West Bengal, India.. Electronic address: moumitakundu1991@iitkgp.ac.in.
  • Das S; Cancer Biology Lab, School of Medical Science and Technology, Indian Institute of Technology Kharagpur (IIT Kharagpur), Kharagpur, West Bengal, India.. Electronic address: subhayan.das@smst.iitkgp.ernet.in.
  • Jena BC; Cancer Biology Lab, School of Medical Science and Technology, Indian Institute of Technology Kharagpur (IIT Kharagpur), Kharagpur, West Bengal, India.. Electronic address: bikashjena@iitkgp.ac.in.
  • Mandal M; Cancer Biology Lab, School of Medical Science and Technology, Indian Institute of Technology Kharagpur (IIT Kharagpur), Kharagpur, West Bengal, India.. Electronic address: mahitosh@smst.iitkgp.ac.in.
Biochim Biophys Acta Rev Cancer ; 1877(2): 188692, 2022 03.
Article en En | MEDLINE | ID: mdl-35122882
Sox family of transcriptional factors play essential functions in development and are implicated in multiple clinical disorders, including cancer. Sox2 being their most prominent member and performing a critical role in reprogramming differentiated adult cells to an embryonic phenotype is frequently upregulated in multiple cancers. High Sox2 levels are detected in breast tumor tissues and correlate with a worse prognosis. In addition, Sox2 expression is connected with resistance to conventional anticancer therapy. Together, it can be said that inhibiting Sox2 expression can reduce the malignant features associated with breast cancer, including invasion, migration, proliferation, stemness, and chemoresistance. This review highlights the critical roles played by the Sox gene family members in initiating or suppressing breast tumor development, while primarily focusing on Sox2 and its role in breast tumor initiation, maintenance, and progression, elucidates the probable mechanisms that control its activity, and puts forward potential therapeutic strategies to inhibit its expression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Biochim Biophys Acta Rev Cancer Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Biochim Biophys Acta Rev Cancer Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos