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Lipopolysaccharide Pretreatment Prevents Medullary Vascular Congestion following Renal Ischemia by Limiting Early Reperfusion of the Medullary Circulation.
McLarnon, Sarah R; Wilson, Katie; Patel, Bansari; Sun, Jingping; Sartain, Christina L; Mejias, Christopher D; Musall, Jacqueline B; Sullivan, Jennifer C; Wei, Qingqing; Chen, Jian-Kang; Hyndman, Kelly A; Marshall, Brendan; Yang, Haichun; Fogo, Agnes B; O'Connor, Paul M.
Afiliación
  • McLarnon SR; Department of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia.
  • Wilson K; Department of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia.
  • Patel B; Department of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia.
  • Sun J; Department of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia.
  • Sartain CL; Department of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia.
  • Mejias CD; Department of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia.
  • Musall JB; Department of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia.
  • Sullivan JC; Department of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia.
  • Wei Q; Department of Cell Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia.
  • Chen JK; Department of Cell Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia.
  • Hyndman KA; Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
  • Marshall B; Department of Cell Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia.
  • Yang H; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Fogo AB; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.
  • O'Connor PM; Department of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia.
J Am Soc Nephrol ; 33(4): 769-785, 2022 04.
Article en En | MEDLINE | ID: mdl-35115326
BACKGROUND: Vascular congestion of the renal medulla-trapped red blood cells in the medullary microvasculature-is a hallmark finding at autopsy in patients with ischemic acute tubular necrosis. Despite this, the pathogenesis of vascular congestion is not well defined. METHODS: In this study, to investigate the pathogenesis of vascular congestion and its role in promoting renal injury, we assessed renal vascular congestion and tubular injury after ischemia reperfusion in rats pretreated with low-dose LPS or saline (control). We used laser Doppler flowmetry to determine whether pretreatment with low-dose LPS prevented vascular congestion by altering renal hemodynamics during reperfusion. RESULTS: We found that vascular congestion originated during the ischemic period in the renal venous circulation. In control animals, the return of blood flow was followed by the development of congestion in the capillary plexus of the outer medulla and severe tubular injury early in reperfusion. Laser Doppler flowmetry indicated that blood flow returned rapidly to the medulla, several minutes before recovery of full cortical perfusion. In contrast, LPS pretreatment prevented both the formation of medullary congestion and its associated tubular injury. Laser Doppler flowmetry in LPS-pretreated rats suggested that limiting early reperfusion of the medulla facilitated this protective effect, because it allowed cortical perfusion to recover and clear congestion from the large cortical veins, which also drain the medulla. CONCLUSIONS: Blockage of the renal venous vessels and a mismatch in the timing of cortical and medullary reperfusion results in congestion of the outer medulla's capillary plexus and promotes early tubular injury after renal ischemia. These findings indicate that hemodynamics during reperfusion contribute to the renal medulla's susceptibility to ischemic injury.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño por Reperfusión / Lesión Renal Aguda Tipo de estudio: Etiology_studies Límite: Animals / Humans Idioma: En Revista: J Am Soc Nephrol Asunto de la revista: NEFROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Georgia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño por Reperfusión / Lesión Renal Aguda Tipo de estudio: Etiology_studies Límite: Animals / Humans Idioma: En Revista: J Am Soc Nephrol Asunto de la revista: NEFROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Georgia Pais de publicación: Estados Unidos