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Longitudinal increase in albumin-bilirubin score is associated with non-malignancy-related mortality and quality of life in patients with liver cirrhosis.
Sakamaki, Akira; Takamura, Masaaki; Sakai, Norihiro; Watanabe, Yusuke; Arao, Yoshihisa; Kimura, Naruhiro; Setsu, Toru; Abe, Hiroyuki; Yokoo, Takeshi; Kamimura, Hiroteru; Tsubata, Shunsuke; Waguri, Nobuo; Ishikawa, Toru; Kawai, Hirokazu; Sugitani, Soichi; Sato, Tomomi; Funakoshi, Kazuhiro; Watanabe, Masashi; Igarashi, Kentarou; Kamimura, Kenya; Tsuchiya, Atsunori; Aoyagi, Yutaka; Terai, Shuji.
Afiliación
  • Sakamaki A; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
  • Takamura M; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
  • Sakai N; Division of Gastroenterology and Hepatology, JA Niigata Kouseiren Nagaoka Chuo General Hospital, Niigata, Japan.
  • Watanabe Y; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
  • Arao Y; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
  • Kimura N; Department of Preemptive Medicine for Digestive Diseases and Healthy Active Life, School of Medicine, Niigata University, Niigata, Japan.
  • Setsu T; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
  • Abe H; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
  • Yokoo T; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
  • Kamimura H; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
  • Tsubata S; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
  • Waguri N; Department of Preemptive Medicine for Digestive Diseases and Healthy Active Life, School of Medicine, Niigata University, Niigata, Japan.
  • Ishikawa T; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
  • Kawai H; Department of Gastroenterology and Hepatology, Tachikawa General Hospital, Niigata, Japan.
  • Sugitani S; Department Gastroenterology and Hepatology, Niigata City General Hospital, Niigata, Japan.
  • Sato T; Division of Gastroenterology and Hepatology, Saiseikai Niigata Hospital, Niigata, Japan.
  • Funakoshi K; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
  • Watanabe M; Department of Internal Medicine, Niigata Prefectural Shibata Hospital, Niigata, Japan.
  • Igarashi K; Department of Gastroenterology and Hepatology, Tachikawa General Hospital, Niigata, Japan.
  • Kamimura K; Department of Internal Medicine, Murakami General Hospital, Niigata, Japan.
  • Tsuchiya A; Division of Gastroenterology and Hepatology, JA Niigata Kouseiren Nagaoka Chuo General Hospital, Niigata, Japan.
  • Aoyagi Y; Department of Internal Medicine, Joetsu General Hospital, Niigata, Japan.
  • Terai S; Division of Gastroenterology and Hepatology, Niigata Prefectural Hospital, Niigata, Japan.
PLoS One ; 17(2): e0263464, 2022.
Article en En | MEDLINE | ID: mdl-35113969
Due to the developments in the treatment for hepatitis, it is possible to prevent the progression of liver fibrosis and improve patients' prognosis even if it has already led to liver cirrhosis (LC). Consequently, a two-step study was conducted. To begin with, a retrospective study was conducted to identify the potential predictors of non-malignancy-related mortality from LC. Then, we prospectively analyzed the validity of these parameters as well as their association with patients' quality of life. In the retrospective study, 89 cases were included, and the multivariate Cox regression analysis indicated that age (P = 0.012), model for end-stage liver disease (MELD) score (P = 0.012), and annual rate of change of the albumin-bilirubin (ALBI) score (P < 0.001) were significantly associated with LC prognosis. In the prospective study, 70 patients were included, and the patients were divided into cirrhosis progression and non-progression groups. The univariate logistic regression analysis indicated the serum procollagen type III N-terminal peptide level (P = 0.040) and MELD score (P = 0.010) were significantly associated with the annual rate of change of the ALBI score. Furthermore, the mean Chronic Liver Disease Questionnaire score worsened from 5.3 to 4.9 in the cirrhosis progression group (P = 0.034). In conclusion, a longitudinal increase in the ALBI score is closely associated with non-malignancy-related mortality and quality of life.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calidad de Vida / Bilirrubina / Albúminas / Cirrosis Hepática Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Aspecto: Patient_preference Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calidad de Vida / Bilirrubina / Albúminas / Cirrosis Hepática Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Aspecto: Patient_preference Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos