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Stem Cells and Tissue Engineering-Based Therapeutic Interventions: Promising Strategies to Improve Peripheral Nerve Regeneration.
de Assis, Ana Carolina Correa; Reis, Amanda Luiza Silva; Nunes, Leonardo Vieira; Ferreira, Luiz Fernando Romanholo; Bilal, Muhammad; Iqbal, Hafiz M N; Soriano, Renato Nery.
Afiliación
  • de Assis ACC; Department of Medicine, Federal University of Juiz de Fora (UFJF-GV), 241 Manoel Byrro St., Governador Valadares, MG, 35032-620, Brazil.
  • Reis ALS; Department of Medicine, Federal University of Juiz de Fora (UFJF-GV), 241 Manoel Byrro St., Governador Valadares, MG, 35032-620, Brazil.
  • Nunes LV; School of Medicine, Federal University of Juiz de Fora (UFJF-JF), Eugênio do Nascimento Avenue, Juiz de Fora, MG, 36038-330, Brazil.
  • Ferreira LFR; Graduate Program in Process Engineering, Tiradentes University (UNIT), 300 Murilo Dantas Ave., Aracaju, SE, 49032-490, Brazil.
  • Bilal M; Institute of Technology and Research (ITP), Tiradentes University (UNIT), 300 Murilo Dantas Ave., Aracaju, SE, 49032-490, Brazil.
  • Iqbal HMN; School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huaian, 223003, China. bilaluaf@hyit.edu.cn.
  • Soriano RN; Tecnologico de Monterrey, School of Engineering and Sciences, Campus Monterrey, Ave. Eugenio Garza Sada 2501, CP 64849, Monterrey, NL , Mexico.
Cell Mol Neurobiol ; 43(2): 433-454, 2023 Mar.
Article en En | MEDLINE | ID: mdl-35107689
Unlike the central nervous system, the peripheral one has the ability to regenerate itself after injury; however, this natural regeneration process is not always successful. In fact, even with some treatments, the prognosis is poor, and patients consequently suffer with the functional loss caused by injured nerves, generating several impacts on their quality of life. In the present review we aimed to address two strategies that may considerably potentiate peripheral nerve regeneration: stem cells and tissue engineering. In vitro studies have shown that pluripotent cells associated with neural scaffolds elaborated by tissue engineering can increase functional recovery, revascularization, remyelination, neurotrophin expression and reduce muscle atrophy. Although these results are very promising, it is important to note that there are some barriers to be circumvented: the host's immune response, the oncogenic properties attributed to stem cells and the duration of the pro-regenerative effects. After all, more studies are still needed to overcome the limitations of these treatments; those that address techniques for manipulating the lesion microenvironment combining different therapies seem to be the most promising and proactive ones.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ingeniería de Tejidos / Traumatismos de los Nervios Periféricos Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Cell Mol Neurobiol Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ingeniería de Tejidos / Traumatismos de los Nervios Periféricos Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Cell Mol Neurobiol Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos