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Prognostic Value of Mesangial C4d Staining in IgA Nephropathy: A Tunisian Study.
Jebali, Hela; Ghabi, Hiba; Mami, Ikram; Fatma, Lilia Ben; Haouet, Slim; Mahjouba, Hend Ben; Hmida, Fethi Ben; Raies, Lamia; Zouaghi, Mohamed Karim.
Afiliación
  • Jebali H; Department of Nephrology; Department of Pathology, Rabta Hospital, Tunis, Tunisia.
  • Ghabi H; Department of Pathology, Rabta Hospital, Tunis, Tunisia.
  • Mami I; Department of Pathology, Rabta Hospital, Tunis, Tunisia.
  • Fatma LB; Department of Pathology, Rabta Hospital, Tunis, Tunisia.
  • Haouet S; Laboratory Research of Kidney Pathology (LR00SP01), Charles Nicolle Hospital, Tunis, Tunisia.
  • Mahjouba HB; Laboratory Research of Kidney Pathology (LR00SP01), Charles Nicolle Hospital, Tunis, Tunisia.
  • Hmida FB; Faculty of Medicine of Tunis, Tunis El Manar University, Tunis, Tunisia.
  • Raies L; Department of Pathology, Rabta Hospital, Tunis, Tunisia.
  • Zouaghi MK; Department of Pathology, Rabta Hospital, Tunis, Tunisia.
Saudi J Kidney Dis Transpl ; 32(3): 691-698, 2021.
Article en En | MEDLINE | ID: mdl-35102910
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease. The main challenge in this disease is the evaluation of prognostic factors for end-stage renal disease (ESRD). The aim of our study was to assess the clinical and prognostic implications of C4d staining in primary IgAN. This was a retrospective study, including adults with primary IgAN. The study was conducted over a period of 10 years. Renal biopsies were scored according to the Oxford classification. C4d immunohistochemical staining was performed. We included 44 patients with a sex ratio of 2.6. The average age was 35.1 ± 11 years. Twenty-two patients (57%) had hypertension (HTN). The median proteinuria was 1.92 g/day. The median of the glomerular filtration rate was 47.66 mL/min/1.73 m2. According to the Oxford classification, mesangial proliferation, endocapillary proliferation, glomerulosclerosis, interstitial fibrosis and/or tubular atrophy and crescents were present in 41%, 36%, 86%, 34%, and 25 % of cases, respectively. We found positive glomerular C4d staining in 25 renal biopsies (57%). Age at diagnosis, mean arterial pressure, HTN, and baseline glomerular filtration rate were not correlated with C4d staining. On the other hand, proteinuria was significantly higher in patients with C4d-positive renal biopsy. The median follow-up duration was 30.5 months. Ten patients (23%) reached ESRD. At univariate analysis, positive C4d staining in more than 25% of glomeruli in patients without C1q deposition in the immunofluorescent study was associated with ESRD. Our study confirms the prognostic value of C4d staining in primary IgAN.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Complemento C4b / Mesangio Glomerular / Glomerulonefritis por IGA / Fallo Renal Crónico Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans / Middle aged Idioma: En Revista: Saudi J Kidney Dis Transpl Año: 2021 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Arabia Saudita
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Complemento C4b / Mesangio Glomerular / Glomerulonefritis por IGA / Fallo Renal Crónico Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans / Middle aged Idioma: En Revista: Saudi J Kidney Dis Transpl Año: 2021 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Arabia Saudita