Your browser doesn't support javascript.
loading
The emergence of COVID-19 associated mucormycosis: a review of cases from 18 countries.
Hoenigl, Martin; Seidel, Danila; Carvalho, Agostinho; Rudramurthy, Shivaprakash M; Arastehfar, Amir; Gangneux, Jean-Pierre; Nasir, Nosheen; Bonifaz, Alexandro; Araiza, Javier; Klimko, Nikolai; Serris, Alexandra; Lagrou, Katrien; Meis, Jacques F; Cornely, Oliver A; Perfect, John R; White, P Lewis; Chakrabarti, Arunaloke.
Afiliación
  • Hoenigl M; Division of Infectious Diseases, ECMM Center of Excellence for Medical Mycology, Medical University of Graz, Graz, Austria.
  • Seidel D; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
  • Carvalho A; Clinical and Translational Fungal Working Group, University of California San Diego, La Jolla, CA, USA.
  • Rudramurthy SM; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.
  • Arastehfar A; Department of Internal Medicine, ECMM Center of Excellence for Medical Mycology, University of Cologne, Cologne, Germany.
  • Gangneux JP; German Centre for Infection Research, Partner Site Bonn-Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Nasir N; Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga, Portugal.
  • Bonifaz A; PT Government Associate Laboratory, Guimarães, Portugal.
  • Araiza J; Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
  • Klimko N; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.
  • Serris A; Environnement et Travail, Univ Rennes, CHU Rennes, Inserm, Institut de Recherche en Santé, Rennes, France.
  • Lagrou K; Section of Adult Infectious Diseases, Department of Medicine, Aga Khan University Karachi, Karachi, Pakistan.
  • Meis JF; Dermatology Service, Hospital General De México Dr Eduardo Liceaga, Mexico City, Mexico.
  • Cornely OA; Dermatology Service, Hospital General De México Dr Eduardo Liceaga, Mexico City, Mexico.
  • Perfect JR; Department of Clinical Mycology, Allergy and Immunology, North Western State Medical University named after II Mechnikov, St Petersburg, Russia.
  • White PL; Department of Infectious Diseases, Necker-Enfants Malades University Hospital, Paris, France.
  • Chakrabarti A; Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.
Lancet Microbe ; 3(7): e543-e552, 2022 07.
Article en En | MEDLINE | ID: mdl-35098179
Reports of COVID-19-associated mucormycosis have been increasing in frequency since early 2021, particularly among patients with uncontrolled diabetes. Patients with diabetes and hyperglycaemia often have an inflammatory state that could be potentiated by the activation of antiviral immunity to SARS-CoV2, which might favour secondary infections. In this Review, we analysed 80 published and unpublished cases of COVID-19-associated mucormycosis. Uncontrolled diabetes, as well as systemic corticosteroid treatment, were present in most patients with COVID-19-associated mucormycosis, and rhino-orbital cerebral mucormycosis was the most frequent disease. Mortality was high at 49%, which was particularly due to patients with pulmonary or disseminated mucormycosis or cerebral involvement. Furthermore, a substantial proportion of patients who survived had life-changing morbidities (eg, loss of vision in 46% of survivors). Our Review indicates that COVID-19-associated mucormycosis is associated with high morbidity and mortality. Diagnosis of pulmonary mucormycosis is particularly challenging, and might be frequently missed in India.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus / COVID-19 / Mucormicosis Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Lancet Microbe Año: 2022 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus / COVID-19 / Mucormicosis Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Lancet Microbe Año: 2022 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Reino Unido