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Progressive Increase Trend in HPV-Related Oropharyngeal Squamous Cell Carcinoma in Brazil.
Pires, Rafael Cardoso; Carvalho, Raiany; Gama, Ricardo Ribeiro; Carvalho, André Lopes; Santos, Carlos Roberto; Capuzzo, Renato de Castro.
Afiliación
  • Pires RC; Head and Neck Surgery Department, Hospital de Câncer de Barretos, Barretos, SP, Brazil.
  • Carvalho R; Researcher Support Center, Hospital de Câncer de Barretos, Barretos, SP, Brazil.
  • Gama RR; Head and Neck Surgery Department, Hospital de Câncer de Barretos, Barretos, SP, Brazil.
  • Carvalho AL; Post-Graduation Program, Hospital de Câncer de Barretos, Barretos, SP, Brazil.
  • Santos CR; Head and Neck Surgery Department, Hospital de Câncer de Barretos, Barretos, SP, Brazil.
  • Capuzzo RC; Head and Neck Surgery Department, Hospital de Câncer de Barretos, Barretos, SP, Brazil.
Int Arch Otorhinolaryngol ; 26(1): e132-e136, 2022 Jan.
Article en En | MEDLINE | ID: mdl-35096170
Introduction The prevalence of oropharyngeal squamous cell carcinoma (OSCC) related to Human Papillomavirus (HPV) is rising in the whole world. Objective To access the prevalence and temporal trend of HPV infection in oropharyngeal cancer by analyzing the expression of the p16 protein. Methods We conducted a transversal study in a Brazilian reference oncology center. The sample consisted of 254 patients with OSCC. The analyzed period was from 2013 to 2017. All patients underwent p16 immunohistochemistry analysis. Results The overall prevalence of HPV-related OSCC was of 31.9%. During the analyzed period, we observed a trend of increasing rates of OSCC that marked positive for p16 immunohistochemistry. The annual prevalence of p16-positive cases was of 20.6% in 2013, 23.9% in 2014, 33.3% in 2015, 38.3% in 2016, and 34.2% in 2017. Most of the patients were stage III and IV (84%). Female patients (odds ratio [OR] = 2.43; 95% confidence interval [CI]: 1.003-5.888; p = 0.049) and younger patients (OR = 2.919; 95%CI: 1.682-5.067; p < 0.005) were associated with a higher risk of HPV-related OSCC. Tobacco consumption had a proportional lower risk of HPV-related OSCC (OR = 0.152; 95%CI: 0063-0.366; p < 0.005). Conclusion We observed an increasing prevalence of HPV-related OSCC in a specialized cancer hospital in Brazil.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies País/Región como asunto: America do sul / Brasil Idioma: En Revista: Int Arch Otorhinolaryngol Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies País/Región como asunto: America do sul / Brasil Idioma: En Revista: Int Arch Otorhinolaryngol Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil