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Chronic Polyhydramnios: A Medical Entity Which Could Be a Model of Muscle Development in Decreased Mechanical Loading Condition.
Sekulic, Slobodan; Jakovljevic, Branislava; Korovljev, Darinka; Simic, Svetlana; Capo, Ivan; Podgorac, Jelena; Martac, Ljiljana; Kesic, Srdjan; Rakic, Srdjan; Petkovic, Branka.
Afiliación
  • Sekulic S; Department of Neurology, University Clinical Center of Vojvodina, Novi Sad, Serbia.
  • Jakovljevic B; Faculty of Medicine of Novi Sad, University of Novi Sad, Novi Sad, Serbia.
  • Korovljev D; Department of Obstetrics, University Clinical Center of Vojvodina, Novi Sad, Serbia.
  • Simic S; Applied Bioenergetics Lab, Faculty of Sport and Physical Education, University of Novi Sad, Novi Sad, Serbia.
  • Capo I; Department of Neurology, University Clinical Center of Vojvodina, Novi Sad, Serbia.
  • Podgorac J; Faculty of Medicine of Novi Sad, University of Novi Sad, Novi Sad, Serbia.
  • Martac L; Faculty of Medicine of Novi Sad, University of Novi Sad, Novi Sad, Serbia.
  • Kesic S; Department of Neurophysiology, Institute for Biological Research "Sinisa Stankovic" - National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia.
  • Rakic S; Department of Neurophysiology, Institute for Biological Research "Sinisa Stankovic" - National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia.
  • Petkovic B; Department of Neurophysiology, Institute for Biological Research "Sinisa Stankovic" - National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Front Physiol ; 12: 810391, 2021.
Article en En | MEDLINE | ID: mdl-35095567
Polyhydramnios is a condition related to an excessive accumulation of amniotic fluid in the third trimester of pregnancy and it can be acute and chronic depending on the duration. Published data suggest that during muscle development, in the stage of late histochemical differentiation decreased mechanical loading cause decreased expression of myosin heavy chain (MHC) type 1 leading to slow-to-fast transition. In the case of chronic polyhydramnios, histochemical muscle differentiation could be affected as a consequence of permanent decreased physical loading. Most affected would be muscles which are the most active i.e., spine extensor muscles and muscles of legs. Long-lasting decreased mechanical loading on muscle should cause decreased expression of MHC type 1 leading to slow-to-fast transition, decreased number of muscle fiber type I especially in extensor muscles of spine and legs. Additionally, because MHC type 1 is present in all skeletal muscles it could lead to various degrees of hypotrophy depending on constituting a percentage of MHC type 1 in affected muscles. These changes in the case of preexisting muscle disorders have the potential to deteriorate the muscle condition additionally. Given these facts, idiopathic chronic polyhydramnios is a rare opportunity to study the influence of reduced physical loading on muscle development in the human fetus. Also, it could be a medical entity to examine the influence of micro- and hypogravity conditions on the development of the fetal muscular system during the last trimester of gestation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Physiol Año: 2021 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Physiol Año: 2021 Tipo del documento: Article Pais de publicación: Suiza