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Chronic exposure to delta-9-tetrahydrocannabinol impacts testicular volume and male reproductive health in rhesus macaques.
Hedges, Jason C; Hanna, Carol B; Bash, Jasper C; Boniface, Emily R; Burch, Fernanda C; Mahalingaiah, Shruthi; Roberts, Victoria H J; Terrobias, Juanito Jose D; Mishler, Emily C; Jensen, Jared V; Easley, Charles A; Lo, Jamie O.
Afiliación
  • Hedges JC; Department of Urology, Oregon Heath & Science University, Portland, Oregon.
  • Hanna CB; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon.
  • Bash JC; Department of Urology, Oregon Heath & Science University, Portland, Oregon.
  • Boniface ER; Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Oregon Health & Science University, Portland, Oregon.
  • Burch FC; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon.
  • Mahalingaiah S; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Massachusetts General Hospital Fertility Center, Department of Obstetrics, Gynecology, and Reproductive Biology, Division of Reproductive Endocrinology and Infertility, Massachusetts General Hospita
  • Roberts VHJ; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon.
  • Terrobias JJD; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon.
  • Mishler EC; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon.
  • Jensen JV; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon.
  • Easley CA; Department of Environmental Health Science, University of Georgia College of Public Health, Athens, Georgia.
  • Lo JO; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon; Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Oregon Health & Science University, Portland, Oregon. Electronic
Fertil Steril ; 117(4): 698-707, 2022 04.
Article en En | MEDLINE | ID: mdl-35090702
OBJECTIVE: To determine the dose-dependent effect of delta-9-tetrahydrocannabinol (THC) exposure on male testes and reproductive health in a nonhuman primate model. DESIGN: Research animal study. SETTING: Research institute. ANIMAL(S): Adult male rhesus macaques 8-10 years of age (n = 6). INTERVENTION(S): Daily edible THC at medically and recreationally relevant doses. MAIN OUTCOME MEASURE(S): Testicular volume and epididymal head width, serum levels of inhibin B, albumin, total testosterone, prolactin, follicle-stimulating hormone, estradiol, and luteinizing hormone; semen volume; and sperm motility, morphology, and concentration. RESULT(S): For each 1 mg/7 kg/day increase in THC dosing, there was a marked loss in total bilateral testicular volume of 11.8 cm3 (95% confidence interval [CI]: 8.3-15.4). In total, average bilateral testicular volume decreased by 58%. Significant dose-response decreases in mean total testosterone level by 1.49 ng/mL (95% CI: 0.83-2.15) and in estradiol level by 3.8 pg/mL (95% CI: 2.2-5.4) were observed, but significant increases in the levels of follicle-stimulating hormone by 0.06 ng/mL (95% CI: 0.02-0.10), luteinizing hormone by 0.16 ng/mL (95% CI: 0.08-0.25), and prolactin by 7.4 ng/mL (95% CI: 3.4-11.3) were observed. There were no statistically significant changes in semen parameters. CONCLUSION(S): In rhesus macaques, chronic exposure to THC resulted in significant dose-response testicular atrophy, increased serum gonadotropin levels, and decreased serum sex steroids, suggestive of primary testicular failure. Further studies are needed to determine if reversal of these observed adverse effects would occur if THC was discontinued and for validation of thefindings in a human cohort.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dronabinol / Salud Reproductiva Límite: Animals / Humans / Male Idioma: En Revista: Fertil Steril Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dronabinol / Salud Reproductiva Límite: Animals / Humans / Male Idioma: En Revista: Fertil Steril Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos