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Risk factors associated with mortality in individuals with type 2 diabetes following an episode of severe hypoglycaemia. Results from a randomised controlled trial.
Pearson, Sam M; Kietsiriroje, Noppadol; Whittam, Beverley; Birch, Rebecca J; Campbell, Matthew D; Ajjan, Ramzi A.
Afiliación
  • Pearson SM; Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
  • Kietsiriroje N; Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
  • Whittam B; Division of Diabetes and Endocrinology, 26686Prince of Songkla University, Hat Yai, Thailand.
  • Birch RJ; 4472Leeds Teaching Hospitals NHS Trust, Leeds, UK.
  • Campbell MD; Leeds Institute of Medical Research at St James's, 4468University of Leeds, Leeds, UK.
  • Ajjan RA; Leeds Institute of Data Analytics, University of Leeds, Leeds, UK.
Diab Vasc Dis Res ; 19(1): 14791641211067415, 2022.
Article en En | MEDLINE | ID: mdl-35089082
BACKGROUND: Severe hypoglycaemia may pose significant risk to individuals with type 2 diabetes (T2D), and evidence surrounding strategies to mitigate this risk is lacking. METHODS: Data was re-analysed from a previous randomised controlled trial studying the impact of nurse-led intervention on mortality following severe hypoglycaemia in the community. A Cox-regression model was used to identify baseline characteristics associated with mortality and to adjust for differences between groups. Kaplan-Meier curves were created to demonstrate differences in outcome between groups across different variables. RESULTS: A total of 124 participants (mean age = 75, 56.5% male) were analysed. In univariate analysis, Diabetes Severity Score (DSS), age and insulin use were baseline factors found to correlate to mortality, while HbA1C and established cardiovascular disease showed no significant correlations. Hazard ratio favoured the intervention (0.68, 95% CI: 0.38-1.19) and in multivariate analysis, only DSS demonstrated a relationship with mortality. Comparison of Kaplan-Meier curves across study groups suggested the intervention is beneficial irrespective of HbA1c, diabetes severity score or age. CONCLUSION: While DSS predicts mortality following severe community hypoglycaemia in individuals with T2D, a structured nurse-led intervention appears to reduce the risk of death across a range of baseline parameters.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Hipoglucemia Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Diab Vasc Dis Res Asunto de la revista: ANGIOLOGIA / ENDOCRINOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Hipoglucemia Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Diab Vasc Dis Res Asunto de la revista: ANGIOLOGIA / ENDOCRINOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido