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Dual control of MAPK activities by AP2C1 and MKP1 MAPK phosphatases regulates defence responses in Arabidopsis.
Ayatollahi, Zahra; Kazanaviciute, Vaiva; Shubchynskyy, Volodymyr; Kvederaviciute, Kotryna; Schwanninger, Manfred; Rozhon, Wilfried; Stumpe, Michael; Mauch, Felix; Bartels, Sebastian; Ulm, Roman; Balazadeh, Salma; Mueller-Roeber, Bernd; Meskiene, Irute; Schweighofer, Alois.
Afiliación
  • Ayatollahi Z; Max Perutz Labs, University of Vienna, Vienna BioCenter, Dr.-Bohr-Gasse 9, A-1030 Vienna, Austria.
  • Kazanaviciute V; Max Perutz Labs, University of Vienna, Vienna BioCenter, Dr.-Bohr-Gasse 9, A-1030 Vienna, Austria.
  • Shubchynskyy V; Max Perutz Labs, University of Vienna, Vienna BioCenter, Dr.-Bohr-Gasse 9, A-1030 Vienna, Austria.
  • Kvederaviciute K; Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio al. 7, LT-10257 Vilnius, Lithuania.
  • Schwanninger M; Department of Chemistry, University of Natural Resources and Applied Life Sciences, Muthgasse 18, A-1190 Vienna, Austria.
  • Rozhon W; Department of Agriculture, Ecotrophology, and Landscape Development, Anhalt University of Applied Sciences, Strenzfelder Allee 28, D-06406 Bernburg, Germany.
  • Stumpe M; Department of Biology, University of Fribourg, Chemin du Musée 10, CH-1700 Fribourg, Switzerland.
  • Mauch F; Department of Biology, University of Fribourg, Chemin du Musée 10, CH-1700 Fribourg, Switzerland.
  • Bartels S; Faculty of Biology, Institute of Biology II, University of Freiburg, Schänzlestraße 1, D-79104 Freiburg, Germany.
  • Ulm R; Department of Botany and Plant Biology, Section of Biology, Faculty of Sciences, University of Geneva, 30 Quai E. Ansermet, CH-1211 Geneva, Switzerland.
  • Balazadeh S; Max-Planck-Institute of Molecular Plant Physiology (MPIMP), Am Mühlenberg 1, D-14476 Potsdam, Germany.
  • Mueller-Roeber B; University of Potsdam, Karl-Liebknecht-Straße 24, D-14476 Potsdam, Germany.
  • Meskiene I; Institute of Biology Leiden (IBL), Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands.
  • Schweighofer A; Max-Planck-Institute of Molecular Plant Physiology (MPIMP), Am Mühlenberg 1, D-14476 Potsdam, Germany.
J Exp Bot ; 73(8): 2369-2384, 2022 04 18.
Article en En | MEDLINE | ID: mdl-35088853
Mitogen-activated protein kinase (MAPK) cascades transmit environmental signals and induce stress and defence responses in plants. These signalling cascades are negatively controlled by specific Ser/Thr protein phosphatases of the type 2C (PP2C) and dual-specificity phosphatase (DSP) families that inactivate stress-induced MAPKs; however, the interplay between phosphatases of these different types has remained unknown. This work reveals that different Arabidopsis MAPK phosphatases, the PP2C-type AP2C1 and the DSP-type MKP1, exhibit both specific and overlapping functions in plant stress responses. Each single mutant, ap2c1 and mkp1, and the ap2c1 mkp1 double mutant displayed enhanced stress-induced activation of the MAPKs MPK3, MPK4, and MPK6, as well as induction of a set of transcription factors. Moreover, ap2c1 mkp1 double mutants showed an autoimmune-like response, associated with increased levels of the stress hormones salicylic acid and ethylene, and of the phytoalexin camalexin. This phenotype was reduced in the ap2c1 mkp1 mpk3 and ap2c1 mkp1 mpk6 triple mutants, suggesting that the autoimmune-like response is due to MAPK misregulation. We conclude that the evolutionarily distant MAPK phosphatases AP2C1 and MKP1 contribute crucially to the tight control of MAPK activities, ensuring appropriately balanced stress signalling and suppression of autoimmune-like responses during plant growth and development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arabidopsis / Proteínas de Arabidopsis Límite: Humans Idioma: En Revista: J Exp Bot Asunto de la revista: BOTANICA Año: 2022 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arabidopsis / Proteínas de Arabidopsis Límite: Humans Idioma: En Revista: J Exp Bot Asunto de la revista: BOTANICA Año: 2022 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Reino Unido