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COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials.
Varikasuvu, Seshadri Reddy; Thangappazham, Balachandar; Vykunta, Alekya; Duggina, Pragathi; Manne, Munikumar; Raj, Hemanth; Aloori, Sowjanya.
Afiliación
  • Varikasuvu SR; Department of Biochemistry, All India Institute of Medical Sciences (Aiims), Deoghar, India.
  • Thangappazham B; COVID-19 volunteering physician, StepOne Ngo, Bengaluru, India.
  • Vykunta A; Heath Centre, Sri Venkateswara University, Tirupathi, India.
  • Duggina P; Technology business incubator, Sri Padmavati Mahila Visvavidyalayam, Tirupathi, India.
  • Manne M; Clinical division, ICMR-National Institute of Nutrition, Hyderabad, India.
  • Raj H; Department of Medicine, Mount Medical Centre, Wantirna, India.
  • Aloori S; Health Education, Telangana State Residential School & College, Telangana, India.
Expert Rev Anti Infect Ther ; 20(6): 907-913, 2022 06.
Article en En | MEDLINE | ID: mdl-35086394
INTRODUCTION: Vitamin D levels have been reported to be associated with COVID-19 susceptibility, severity, and mortality events. We performed a meta-analysis of randomized controlled trials (RCTs) to evaluate the use of vitamin D intervention on COVID-19 outcomes. AREAS COVERED: Literature search was conducted using PubMed, Cochrane library, and ClinicalTrials.gov databases. We included RCTs reporting the use of vitamin D intervention to control/placebo group in COVID-19. The study was registered at PROSPERO: CRD42021271461. EXPERT OPINION: A total of 6 RCTs with 551 COVID-19 patients were included. The overall collective evidence pooling all the outcomes across all RCTs indicated the beneficial use of vitamin D intervention in COVID-19 (relative risk, RR = 0.60, 95% CI 0.40 to 0.92, Z = 2.33, p = 0.02, I2 = 48%). The rates of RT-CR positivity were significantly decreased in the intervention group as compared to the non-vitamin D groups (RR = 0.46, 95% CI 0.24 to 0.89, Z = 2.31, p = 0.02, I2 = 0%). Conclusively, COVID-19 patients supplemented with vitamin D are more likely to demonstrate fewer rates of ICU admission, mortality events, and RT-PCR positivity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 Tipo de estudio: Clinical_trials / Etiology_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Expert Rev Anti Infect Ther Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2022 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 Tipo de estudio: Clinical_trials / Etiology_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Expert Rev Anti Infect Ther Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2022 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido