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Associations of Chinese Herbal Medicine Use with the Risks of Acute Exacerbation and Mortality in Patients with Chronic Obstructive Pulmonary Disease: A Nationwide Retrospective Cohort Study.
Hung, Jui-Hung; Chen, Wei-Chieh; Lin, Mei-Chen; Chuang, Hsiao-Mei; Wang, Jiun-Long; Fu, Pin-Kuei; Lin, Chun-Pang; Huang, Sheng-Teng.
Afiliación
  • Hung JH; Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan.
  • Chen WC; Department of Chinese Medicine, An-Nan Hospital, China Medical University, Tainan, Taiwan.
  • Lin MC; Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
  • Chuang HM; Department of Chinese Medicine, An-Nan Hospital, China Medical University, Tainan, Taiwan.
  • Wang JL; Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Fu PK; Department of Critical Care Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Lin CP; Department of Chinese Medicine, An-Nan Hospital, China Medical University, Tainan, Taiwan.
  • Huang ST; Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan.
J Integr Complement Med ; 28(1): 77-86, 2022 Jan.
Article en En | MEDLINE | ID: mdl-35085024
Objectives: This study aimed to assess the correlation of exacerbation and the mortality rate in patients with chronic obstructive pulmonary disease (COPD) between biomedical treatments with or without Chinese herbal medicine (CHM) as an adjunct. Design: A total of 81,261 COPD patients were identified from the National Health Insurance Research Database in Taiwan between 2001 and 2012. After screening and matching, 3176 COPD patients were included in the study. Statistical analyses were performed to assess the differences in the baseline characteristics. The authors used the Cox proportional hazard regression analysis to calculate the risks of mortality and hospitalization due to acute exacerbation of COPD within 1 year between a CHM user cohort and non-CHM user cohort. The cumulative incidence of mortality in COPD patients with or without CHM treatment was calculated by the Kaplan-Meier method. Results: COPD patients in the CHM user cohort demonstrated a significantly lower risk of mortality (p < 0.001) and acute exacerbation (p < 0.05), compared with the non-CHM user cohort. In addition, the CHM users exhibited a reduced cumulative incidence of mortality compared with the non-CHM user cohort (p < 0.001). Xiao Qing Long Tang and Fritillariae thunbergii were the most common Chinese herbal formula and single Chinese herb prescribed for COPD patients. Conclusion: Combining CHM with biomedical treatment might reduce the risk of acute exacerbation and incidence of mortality in patients with COPD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Enfermedad Pulmonar Obstructiva Crónica Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Integr Complement Med Año: 2022 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Enfermedad Pulmonar Obstructiva Crónica Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Integr Complement Med Año: 2022 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos