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Maternal soybean genistein on prevention of later-life breast cancer through inherited epigenetic regulations.
Chen, Min; Li, Shizhao; Srinivasasainagendra, Vinodh; Sharma, Manvi; Li, Zhenhai; Tiwari, Hemant; Tollefsbol, Trygve O; Li, Yuanyuan.
Afiliación
  • Chen M; Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Li S; Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Srinivasasainagendra V; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Sharma M; Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Li Z; Department of Obstetrics, Gynecology & Women's Heath, University of Missouri, Columbia, Missouri, USA.
  • Tiwari H; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Tollefsbol TO; Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Li Y; Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Carcinogenesis ; 43(3): 190-202, 2022 04 25.
Article en En | MEDLINE | ID: mdl-35084457
Breast cancer has strong developmental origins and maternal nutrition composition may influence later-life breast cancer risk in the offspring. Our study focused on a bioactive dietary component, genistein (GE) enriched in soybean products, to investigate specific timing of maternal GE exposure that may influence preventive efficacy of GE on offspring breast cancer later in life, and to explore the potential epigenetic mechanisms. Our results indicate a time-dependent effect of maternal GE exposure on early-life breast cancer development in offspring mice. Through integrated transcriptome and methylome analyses, we identified several candidate genes showing significantly differential gene expression and DNA methylation changes. We further found maternal long-term GE treatment can induce inherited epigenetic landmark changes in a candidate tumor suppressor gene, Trp63, resulting in transcriptional activation of Trp63 and induction of the downstream target genes. Our results suggest that maternal long-term exposure to soybean GE may influence early-life epigenetic reprogramming processes, which may contribute to its temporal preventive effects on breast cancer in the offspring. This study provides important mechanistic insights into an appropriate maternal administration of soybean products on prevention of breast cancer later in offspring life.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fabaceae / Neoplasias Límite: Animals Idioma: En Revista: Carcinogenesis Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fabaceae / Neoplasias Límite: Animals Idioma: En Revista: Carcinogenesis Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido