Your browser doesn't support javascript.
loading
Interactions between human milk oligosaccharides, microbiota and immune factors in milk of women with and without mastitis.
Castro, Irma; García-Carral, Cristina; Furst, Annalee; Khwajazada, Sadaf; García, Janneiry; Arroyo, Rebeca; Ruiz, Lorena; Rodríguez, Juan M; Bode, Lars; Fernández, Leónides.
Afiliación
  • Castro I; Departament of Nutrition and Food Science, Complutense University of Madrid, Madrid, Spain.
  • García-Carral C; Departament of Nutrition and Food Science, Complutense University of Madrid, Madrid, Spain.
  • Furst A; Probisearch S.L., Tres Cantos, Spain.
  • Khwajazada S; Department of Pediatrics and Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence, University of California San Diego, La Jolla, CA, USA.
  • García J; Department of Pediatrics and Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence, University of California San Diego, La Jolla, CA, USA.
  • Arroyo R; Department of Pediatrics and Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence, University of California San Diego, La Jolla, CA, USA.
  • Ruiz L; Departament of Nutrition and Food Science, Complutense University of Madrid, Madrid, Spain.
  • Rodríguez JM; Department of Microbiology and Biochemistry of Dairy Products, Institute of Dairy Products of Asturias, IPLA-CSIC, Villaviciosa, Spain.
  • Bode L; Departament of Nutrition and Food Science, Complutense University of Madrid, Madrid, Spain.
  • Fernández L; Department of Pediatrics and Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence, University of California San Diego, La Jolla, CA, USA. lbode@health.ucsd.edu.
Sci Rep ; 12(1): 1367, 2022 01 25.
Article en En | MEDLINE | ID: mdl-35079053
Lactational mastitis is an excellent target to study possible interactions between HMOs, immune factors and milk microbiota due to the infectious and inflammatory nature of this condition. In this work, microbiological, immunological and HMO profiles of milk samples from women with (MW) or without (HW) mastitis were compared. Secretor status in women (based on HMO profile) was not associated to mastitis. DFLNH, LNFP II and LSTb concentrations in milk were higher in samples from HW than from MW among Secretor women. Milk from HW was characterized by a low bacterial load (dominated by Staphylococcus epidermidis and streptococci), high prevalence of IL10 and IL13, and low sialylated HMO concentration. In contrast, high levels of staphylococci, streptococci, IFNγ and IL12 characterized milk from MW. A comparison between subacute (SAM) and acute (AM) mastitis cases revealed differences related to the etiological agent (S. epidermidis in SAM; Staphylococcus aureus in AM), milk immunological profile (high content of IL10 and IL13 in SAM and IL2 in AM) and milk HMOs profile (high content of 3FL in SAM and of LNT, LNnT, and LSTc in AM). These results suggest that microbiological, immunological and HMOs profiles of milk are related to mammary health of women.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligosacáridos / Staphylococcus epidermidis / Mastitis / Leche Humana Tipo de estudio: Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligosacáridos / Staphylococcus epidermidis / Mastitis / Leche Humana Tipo de estudio: Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido