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Enteropathogenic Escherichia coli Mediates CoCrMo Particle-Induced Peri-Implant Osteolysis by Increasing Peripheral 5-HT.
Xue, Kaiwen; Tao, Ruijie; Wu, Qi; Zhang, Lei; Sun, Zhongyang; Yu, Xing; Meng, Jia; Bao, Nirong; Zhao, Jianning.
Afiliación
  • Xue K; Department of Orthopaedics, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
  • Tao R; Department of Orthopaedics, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
  • Wu Q; Department of Orthopaedics, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
  • Zhang L; Department of Orthopaedics, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
  • Sun Z; Department of Orthopaedics, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
  • Yu X; Department of Orthopaedics, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
  • Meng J; Department of Orthopaedics, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
  • Bao N; Department of Orthopaedics, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
  • Zhao J; Department of Orthopaedics, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
Front Cell Infect Microbiol ; 11: 796679, 2021.
Article en En | MEDLINE | ID: mdl-35071047
The human gut microbiota has been proven to have great effects on the regulation of bone health. However, the association between gut microbiota and particle-induced osteolysis, which is the primary cause of aseptic loosening, is still unknown. In this study, we used a combination of wide-spectrum antibiotics to eliminate the majority of gut microbiota and found that reduction of gut commensal bacteria significantly alleviated the progression of osteolysis, in which anaerobe was the biggest culprit in the exacerbation of osteolysis. Furthermore, colonization of enteropathogenic Escherichia coli (EPEC), a subspecies of anaerobe, could promote the development of particle-induced osteolysis by increasing the secretion of peripheral 5-hydroxytryptamine (5-HT) from the colon. Elevated 5-HT level decreased the phosphorylation of CREB and inhibited the proliferation of osteoblasts. Collectively, these results indicated EPEC colonization suppressed the bone formation and aggravated particle-induced osteolysis in vivo. Thus, clearance of EPEC is expected to become a potential preventive approach to treat debris-induced osteolysis and aseptic loosening.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteólisis / Escherichia coli Enteropatógena Límite: Animals / Humans Idioma: En Revista: Front Cell Infect Microbiol Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteólisis / Escherichia coli Enteropatógena Límite: Animals / Humans Idioma: En Revista: Front Cell Infect Microbiol Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza