Your browser doesn't support javascript.
loading
CXCR4 Mediates Enhanced Cell Migration in CALM-AF10 Leukemia.
Fertal, Shelby A; Zaidi, Sayyed K; Stein, Janet L; Stein, Gary S; Heath, Jessica L.
Afiliación
  • Fertal SA; Department of Pediatrics, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
  • Zaidi SK; Department of Biochemistry, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
  • Stein JL; University of Vermont Cancer Center, Burlington, VT, United States.
  • Stein GS; Department of Biochemistry, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
  • Heath JL; University of Vermont Cancer Center, Burlington, VT, United States.
Front Oncol ; 11: 708915, 2021.
Article en En | MEDLINE | ID: mdl-35070954
Leukemia transformed by the CALM-AF10 chromosomal translocation is characterized by a high incidence of extramedullary disease, central nervous system (CNS) relapse, and a poor prognosis. Invasion of the extramedullary compartment and CNS requires leukemia cell migration out of the marrow and adherence to the cells of the local tissue. Cell adhesion and migration are increasingly recognized as contributors to leukemia development and therapeutic response. These processes are mediated by a variety of cytokines, chemokines, and their receptors, forming networks of both secreted and cell surface factors. The cytokines and cytokine receptors that play key roles in CALM-AF10 driven leukemia are unknown. We find high cell surface expression of the cytokine receptor CXCR4 on leukemia cells expressing the CALM-AF10 oncogenic protein, contributing to the migratory nature of this leukemia. Our discovery of altered cytokine receptor expression and function provides valuable insight into the propagation and persistence of CALM-AF10 driven leukemia.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Oncol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Oncol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza