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The Role of Oxidative Stress in Intervertebral Disc Degeneration.
Cao, Guoshuai; Yang, Sidong; Cao, Jianye; Tan, Zixuan; Wu, Linyu; Dong, Fang; Ding, Wenyuan; Zhang, Feng.
Afiliación
  • Cao G; Department of Clinical Medicine, Hebei Medical University, Shijiazhuang 050051, China.
  • Yang S; Department of Spine Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
  • Cao J; Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
  • Tan Z; Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
  • Wu L; Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
  • Dong F; Department of Clinical Laboratory Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
  • Ding W; Department of Spine Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
  • Zhang F; Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
Oxid Med Cell Longev ; 2022: 2166817, 2022.
Article en En | MEDLINE | ID: mdl-35069969
Intervertebral disc degeneration is a very common type of degenerative disease causing severe socioeconomic impact, as well as a major cause of discogenic low back pain and herniated discs, placing a heavy burden on patients and the clinicians who treat them. IDD is known to be associating with a complex process involving in extracellular matrix and cellular damage, and in recent years, there is increasing evidence that oxidative stress is an important activation mechanism of IDD and that reactive oxygen and reactive nitrogen species regulate matrix metabolism, proinflammatory phenotype, autophagy and senescence in intervertebral disc cells, apoptosis, autophagy, and senescence. Despite the tremendous efforts of researchers within the field of IDD pathogenesis, the proven strategies to prevent and treat this disease are still very limited. Up to now, several antioxidants have been proved to be effective for alleviating IDD. In this article, we discussed that oxidative stress accelerates disc degeneration by influencing aging, inflammation, autophagy, and DNA methylation, and summarize some antioxidant therapeutic measures for IDD, indicating that antioxidant therapy for disc degeneration holds excellent promise.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Oxidativo / Degeneración del Disco Intervertebral Límite: Animals / Humans Idioma: En Revista: Oxid Med Cell Longev Asunto de la revista: METABOLISMO Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Oxidativo / Degeneración del Disco Intervertebral Límite: Animals / Humans Idioma: En Revista: Oxid Med Cell Longev Asunto de la revista: METABOLISMO Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos