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Myocardial infarction and stroke risks in multiple sclerosis patients: A two-sample Mendelian randomization study.
Peng, Haoxin; Wu, Xiangrong; Wen, Yaokai; Lin, Jinsheng; Guan, Wenhui.
Afiliación
  • Peng H; Nanshan School, Guangzhou Medical University, Jingxiu Road, Panyu District, Guangzhou 511436, China; The First Affiliated Hospital of Guangzhou Medical University, Yanjiang Road, Yuexiu Distinct, Guangzhou 511436, China. Electronic address: penghx2000@126.com.
  • Wu X; Nanshan School, Guangzhou Medical University, Jingxiu Road, Panyu District, Guangzhou 511436, China; The First Affiliated Hospital of Guangzhou Medical University, Yanjiang Road, Yuexiu Distinct, Guangzhou 511436, China.
  • Wen Y; School of Medicine, Tongji University, Shanghai 200092, China; Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai 200433, China.
  • Lin J; Nanshan School, Guangzhou Medical University, Jingxiu Road, Panyu District, Guangzhou 511436, China; The First Affiliated Hospital of Guangzhou Medical University, Yanjiang Road, Yuexiu Distinct, Guangzhou 511436, China.
  • Guan W; Nanshan School, Guangzhou Medical University, Jingxiu Road, Panyu District, Guangzhou 511436, China; The First Affiliated Hospital of Guangzhou Medical University, Yanjiang Road, Yuexiu Distinct, Guangzhou 511436, China.
Mult Scler Relat Disord ; 58: 103501, 2022 Feb.
Article en En | MEDLINE | ID: mdl-35066269
Observational studies indicated multiple sclerosis (MS) patients may have a higher risk of myocardial infarction (MI) and stroke than the general population, whereas the previously reported findings were inconsistent. Using two-sample Mendelian randomization (MR) analysis with genetic data from large-scale genome-wide association studies (International Multiple Sclerosis Genetics Consortium containing 14,498 MS cases, Coronary ARtery DIsease Genome wide Replication and Meta-analysis plus The Coronary Artery Disease Genetics consortium containing 43,676 MI cases and 40,585 stroke cases), we found that MS was causally associated with an increased risk of MI (OR = 1.03; 95%CI 1.00-1.06; P = 0.0243), directionally consistent in the weighted median, MR-Egger, and the MR-PRESSO methods. No causal association between MS and stroke was observed (OR = 1.01; 95%CI 0.99-1.04; P = 0.2974). Therefore, timelier and more effective measures should be conducted among MS patients to decrease the burden of both diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Accidente Cerebrovascular / Esclerosis Múltiple / Infarto del Miocardio Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Mult Scler Relat Disord Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Accidente Cerebrovascular / Esclerosis Múltiple / Infarto del Miocardio Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Mult Scler Relat Disord Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos