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Hygromycin A derivatives isolated from Streptomyces sp. PC-22 in the rhizosphere soil of Pulsatilla chinensis.
Ding, Xiaoqian; Yuan, Tianjie; Chen, Weiwei; Wang, Xiachang; Chu, Yiwen; Liu, Xiao; Hu, Yang; Hu, Lihong.
Afiliación
  • Ding X; Jiangsu Key Laboratory for Functional Substances of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, People's Republic of China.
  • Yuan T; Jiangsu Key Laboratory for Functional Substances of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, People's Republic of China.
  • Chen W; Jiangsu Province Hospital of Chinese Medicine affiliated to Nanjing University of Chinese Medicine, Nanjing, 210029, People's Republic of China.
  • Wang X; Jiangsu Key Laboratory for Functional Substances of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, People's Republic of China.
  • Chu Y; Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu, 610052, People's Republic of China.
  • Liu X; Jiangsu Key Laboratory for Functional Substances of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, People's Republic of China. 300999@njucm.edu.cn.
  • Hu Y; Jiangsu Key Laboratory for Functional Substances of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, People's Republic of China. huyang@njucm.edu.cn.
  • Hu L; Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu, 610052, People's Republic of China. huyang@njucm.edu.cn.
J Antibiot (Tokyo) ; 75(3): 176-180, 2022 03.
Article en En | MEDLINE | ID: mdl-35064242
On the basis of the one strain-many compounds (OSMAC) strategy, two new hygromycin A derivatives (3, 4), together with six known compounds were isolated from a medicinal plant inter rhizospheric Streptomyces in Pulsatilla chinensis. The structures of 3 and 4 were elucidated using NMR and HRESIMS analyses. A plausible biosynthetic pathway for these compounds was discussed. All the compounds were evaluated for their antimicrobial and cytotoxic activities. Compound 5 exhibited potent inhibitory activity against S. aureus and B. subtilis with the MICs of 16 and 8 µg ml-1, while 4 showed weak inhibitory activity against S. aureus.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Suelo / Streptomyces / Higromicina B / Cinamatos / Pulsatilla Idioma: En Revista: J Antibiot (Tokyo) Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Suelo / Streptomyces / Higromicina B / Cinamatos / Pulsatilla Idioma: En Revista: J Antibiot (Tokyo) Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido