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Mitochondrial Membrane Remodeling.
Yang, Ziyun; Wang, Liang; Yang, Cheng; Pu, Shiming; Guo, Ziqi; Wu, Qiong; Zhou, Zuping; Zhao, Hongxia.
Afiliación
  • Yang Z; School of Life Sciences, Guangxi Normal University, Guilin, China.
  • Wang L; Guangxi Universities, Key Laboratory of Stem Cell and Biopharmaceutical Technology, Guangxi Normal University, Guilin, China.
  • Yang C; Research Center for Biomedical Sciences, Guangxi Normal University, Guilin, China.
  • Pu S; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical School, Sichuan University, High-Tech Development Zone, Chengdu, China.
  • Guo Z; School of Life Sciences, Guangxi Normal University, Guilin, China.
  • Wu Q; Guangxi Universities, Key Laboratory of Stem Cell and Biopharmaceutical Technology, Guangxi Normal University, Guilin, China.
  • Zhou Z; Research Center for Biomedical Sciences, Guangxi Normal University, Guilin, China.
  • Zhao H; School of Life Sciences, Guangxi Normal University, Guilin, China.
Front Bioeng Biotechnol ; 9: 786806, 2021.
Article en En | MEDLINE | ID: mdl-35059386
Mitochondria are key regulators of many important cellular processes and their dysfunction has been implicated in a large number of human disorders. Importantly, mitochondrial function is tightly linked to their ultrastructure, which possesses an intricate membrane architecture defining specific submitochondrial compartments. In particular, the mitochondrial inner membrane is highly folded into membrane invaginations that are essential for oxidative phosphorylation. Furthermore, mitochondrial membranes are highly dynamic and undergo constant membrane remodeling during mitochondrial fusion and fission. It has remained enigmatic how these membrane curvatures are generated and maintained, and specific factors involved in these processes are largely unknown. This review focuses on the current understanding of the molecular mechanism of mitochondrial membrane architectural organization and factors critical for mitochondrial morphogenesis, as well as their functional link to human diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Bioeng Biotechnol Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Bioeng Biotechnol Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza