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Japanese Type 1 Diabetes Database Study (TIDE-J): rationale and study design.
Chujo, Daisuke; Imagawa, Akihisa; Yasuda, Kazuki; Abiru, Norio; Awata, Takuya; Fukui, Tomoyasu; Ikegami, Hiroshi; Kawasaki, Eiji; Katsuki, Takeshi; Kobayashi, Tetsuro; Kozawa, Junji; Nagasawa, Kan; Ohtsu, Hiroshi; Oikawa, Yoichi; Osawa, Haruhiko; Shimada, Akira; Shimoda, Masayuki; Takahashi, Kazuma; Tsuchiya, Kyoichiro; Tsujimoto, Tetsuro; Yasuda, Hisafumi; Hanafusa, Toshiaki; Kajio, Hiroshi.
Afiliación
  • Chujo D; Department of Diabetes, Endocrinology, and Metabolism, National Center for Global Health and Medicine, 1-21-1, Toyama, Shinjuku, Tokyo, 162-8655 Japan.
  • Imagawa A; Center for Clinical Research, Toyama University Hospital, Toyama, Japan.
  • Yasuda K; Islet Cell Transplantation Project, National Center for Global Health and Medicine, Tokyo, Japan.
  • Abiru N; Department of Internal Medicine (I), Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
  • Awata T; Department of Diabetes, Endocrinology, and Metabolism, Kyorin University, Mitaka, Japan.
  • Fukui T; Department of Endocrinology and Metabolism, Nagasaki University Hospital, Nagasaki, Japan.
  • Ikegami H; Center for University-Wide Education, School of Health and Social Service, Saitama Prefectural University, Saitama, Japan.
  • Kawasaki E; Division of Diabetes and Endocrinology, Showa University School of Medicine, Tokyo, Japan.
  • Katsuki T; Department of Endocrinology, Metabolism and Diabetes, Faculty of Medicine, Kindai University, Higashi-Osaka, Japan.
  • Kobayashi T; Diabetes Center, Shin-Koga Hospital, Kurume, Japan.
  • Kozawa J; Department of Diabetes and Endocrinology, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
  • Nagasawa K; Division of Immunology and Molecular Medicine, Okinaka Memorial Institute for Medical Research, Tokyo, Japan.
  • Ohtsu H; Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Japan.
  • Oikawa Y; Division of Diabetes, Metabolism, and Endocrine Medicine Field, Iwate Medical University, Shiwa, Japan.
  • Osawa H; Department of Date Science, National Center for Global Health and Medicine, Tokyo, Japan.
  • Shimada A; Department of Endocrinology and Diabetes, School of Medicine, Saitama Medical University, Iruma, Japan.
  • Shimoda M; Department of Diabetes and Molecular Genetics, Ehime University Graduate School of Medicine, Toon, Japan.
  • Takahashi K; Department of Endocrinology and Diabetes, School of Medicine, Saitama Medical University, Iruma, Japan.
  • Tsuchiya K; Islet Cell Transplantation Project, National Center for Global Health and Medicine, Tokyo, Japan.
  • Tsujimoto T; Iwate Prefectural University, Takizawa, Japan.
  • Yasuda H; Department of Diabetes and Endocrinology, University of Yamanashi Hospital, Yamanashi, Japan.
  • Hanafusa T; Department of Diabetes and Endocrinology, Toranomon Hospital Kajigaya, Kawasaki, Japan.
  • Kajio H; Division of Health Sciences, Department of Public Health, Kobe University Graduate School of Health Sciences, Kobe, Japan.
Diabetol Int ; 13(1): 288-294, 2022 Jan.
Article en En | MEDLINE | ID: mdl-35059265
Type 1 diabetes (T1D) is classified into three subtypes: acute-onset, slowly progressive, and fulminant T1D, according to the heterogeneity of clinical course in Japan. Although several cross-sectional databases of T1D have been reported, prospective longitudinal databases to investigate clinical outcomes are lacking in our country. Therefore, we herein construct multi-center prospective longitudinal database of the three subtypes of T1D, accompanied with genetic information and biobanking, which is named Japanese Type 1 Diabetes Database Study (TIDE-J). Inclusion criteria of this study are as follows: (1) the duration of T1D was less than 5 years, (2) the patients had one or more islet-related autoantibodies and/or fasting serum C-peptide levels were less than 1.0 ng/mL, (3) the patients could clearly understand the study consent in writing. In the TIDE-J, clinical data, including glycemic control, endogenous insulin secretion, islet-related autoantibodies, diabetic complications, and treatment, are collected annually using electric data collection system, which is named REDCap. Furthermore, HLA genotypes of each participant were analyzed at entry and the blood samples were stored for assessing exploratory markers and further genetic analysis annually. The TIDE-J certainly helps in revealing distinct clinical course of each T1D subtype. Moreover, this database may help in identifying novel markers for diagnosing each subtype of T1D and predicting clinical outcomes (including pancreatic beta cell function and disease severity) in patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Prognostic_studies Idioma: En Revista: Diabetol Int Año: 2022 Tipo del documento: Article Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Prognostic_studies Idioma: En Revista: Diabetol Int Año: 2022 Tipo del documento: Article Pais de publicación: Japón