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Significant changes in macrophage and CD8 T cell densities in primary prostate tumors 2 weeks after SBRT.
Kane, Nathanael; Romero, Tahmineh; Diaz-Perez, Silvia; Rettig, Matthew B; Steinberg, Michael L; Kishan, Amar U; Schaue, Dorthe; Reiter, Robert E; Knudsen, Beatrice S; Nickols, Nicholas G.
Afiliación
  • Kane N; Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
  • Romero T; Statistic Core, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
  • Diaz-Perez S; Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
  • Rettig MB; Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
  • Steinberg ML; Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
  • Kishan AU; Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
  • Schaue D; Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
  • Reiter RE; Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
  • Knudsen BS; Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
  • Nickols NG; Department of Pathology, University of Utah, Salt Lake City, UT, USA.
Prostate Cancer Prostatic Dis ; 26(1): 207-209, 2023 03.
Article en En | MEDLINE | ID: mdl-35058580
BACKGROUND: Radiotherapy impacts the local immune response to cancers. Prostate Stereotactic Body Radiotherapy (SBRT) is a highly focused method to deliver radiotherapy often used to treat prostate cancer. This is the first direct comparison of immune cells within prostate cancers before and after SBRT in patients. METHODS: Prostate cancers before and 2 weeks after SBRT are interrogated by multiplex immune fluorescence targeting various T cells and macrophages markers and analyzed by cell and pixel density, as part of a clinical trial of SBRT neoadjuvant to radical prostatectomy. RESULTS: Two weeks after SBRT, CD68, and CD163 macrophages are significantly increased while CD8 T cells are decreased. SBRT markedly alters the immune environment within prostate cancers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Radiocirugia Límite: Humans / Male Idioma: En Revista: Prostate Cancer Prostatic Dis Asunto de la revista: ENDOCRINOLOGIA / NEOPLASIAS / UROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Radiocirugia Límite: Humans / Male Idioma: En Revista: Prostate Cancer Prostatic Dis Asunto de la revista: ENDOCRINOLOGIA / NEOPLASIAS / UROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido