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Inhibitory Effect of Etravirine, a Non-Nucleoside Reverse Transcriptase Inhibitor, via Anterior Gradient Protein 2 Homolog Degradation against Ovarian Cancer Metastasis.
Ly, Thanh Truong Giang; Yun, Jisoo; Ha, Jong-Seong; Kim, Yeon-Ju; Jang, Woong-Bi; Van Le, Thi Hong; Rethineswaran, Vinoth Kumar; Choi, Jaewoo; Kim, Jae-Ho; Min, Sang-Hyun; Lee, Dong-Hyung; Yang, Ju-Seok; Chung, Joo-Seop; Kwon, Sang-Mo.
Afiliación
  • Ly TTG; Laboratory for Vascular Medicine and Stem Cell Biology, Department of Physiology, Medical Research Institute, School of Medicine, Pusan National University, Yangsan 50612, Korea.
  • Yun J; Convergence Stem Cell Research Center, Pusan National University, Yangsan 50612, Korea.
  • Ha JS; Laboratory for Vascular Medicine and Stem Cell Biology, Department of Physiology, Medical Research Institute, School of Medicine, Pusan National University, Yangsan 50612, Korea.
  • Kim YJ; Convergence Stem Cell Research Center, Pusan National University, Yangsan 50612, Korea.
  • Jang WB; Laboratory for Vascular Medicine and Stem Cell Biology, Department of Physiology, Medical Research Institute, School of Medicine, Pusan National University, Yangsan 50612, Korea.
  • Van Le TH; Convergence Stem Cell Research Center, Pusan National University, Yangsan 50612, Korea.
  • Rethineswaran VK; Laboratory for Vascular Medicine and Stem Cell Biology, Department of Physiology, Medical Research Institute, School of Medicine, Pusan National University, Yangsan 50612, Korea.
  • Choi J; Convergence Stem Cell Research Center, Pusan National University, Yangsan 50612, Korea.
  • Kim JH; Laboratory for Vascular Medicine and Stem Cell Biology, Department of Physiology, Medical Research Institute, School of Medicine, Pusan National University, Yangsan 50612, Korea.
  • Min SH; Convergence Stem Cell Research Center, Pusan National University, Yangsan 50612, Korea.
  • Lee DH; Laboratory for Vascular Medicine and Stem Cell Biology, Department of Physiology, Medical Research Institute, School of Medicine, Pusan National University, Yangsan 50612, Korea.
  • Yang JS; Convergence Stem Cell Research Center, Pusan National University, Yangsan 50612, Korea.
  • Chung JS; Laboratory for Vascular Medicine and Stem Cell Biology, Department of Physiology, Medical Research Institute, School of Medicine, Pusan National University, Yangsan 50612, Korea.
  • Kwon SM; Convergence Stem Cell Research Center, Pusan National University, Yangsan 50612, Korea.
Int J Mol Sci ; 23(2)2022 Jan 15.
Article en En | MEDLINE | ID: mdl-35055132
Anterior gradient protein 2 homolog (AGR2), an endoplasmic reticulum protein, is secreted in the tumor microenvironment. AGR2 is a member of the disulfide isomerase family, is highly expressed in multiple cancers, and promotes cancer metastasis. In this study, we found that etravirine, which is a non-nucleoside reverse transcriptase inhibitor, could induce AGR2 degradation via autophagy. Moreover, etravirine diminished proliferation, migration, and invasion in vitro. Moreover, in an orthotopic xenograft mouse model, the combination of etravirine and paclitaxel significantly suppressed cancer progression and metastasis. This drug may be a promising therapeutic agent for the treatment of ovarian cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Pirimidinas / Paclitaxel / Proteínas Oncogénicas / Inhibidores de la Transcriptasa Inversa / Mucoproteínas / Nitrilos Límite: Animals / Female / Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Pirimidinas / Paclitaxel / Proteínas Oncogénicas / Inhibidores de la Transcriptasa Inversa / Mucoproteínas / Nitrilos Límite: Animals / Female / Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article Pais de publicación: Suiza