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Overexpression of the SARS-CoV-2 receptor angiotensin converting enzyme 2 in cardiomyocytes of failing hearts.
Vukusic, Kristina; Thorsell, Annika; Muslimovic, Aida; Jonsson, Marianne; Dellgren, Göran; Lindahl, Anders; Sandstedt, Joakim; Hammarsten, Ola.
Afiliación
  • Vukusic K; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Bruna stråket 16, 41345, Gothenburg, Sweden. kristina.vukusic@gu.se.
  • Thorsell A; Proteomics Core Facility at Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
  • Muslimovic A; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Bruna stråket 16, 41345, Gothenburg, Sweden.
  • Jonsson M; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Bruna stråket 16, 41345, Gothenburg, Sweden.
  • Dellgren G; Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Lindahl A; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Sandstedt J; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Bruna stråket 16, 41345, Gothenburg, Sweden.
  • Hammarsten O; Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden.
Sci Rep ; 12(1): 965, 2022 01 19.
Article en En | MEDLINE | ID: mdl-35046458
Hospitalized patients who die from Covid-19 often have pre-existing heart disease. The SARS-CoV-2 virus is dependent on the ACE2 receptor to be able to infect cells. It is possible that the strong link between cardiovascular comorbidities and a poor outcome following a SARS-CoV-2 infection is sometimes due to viral myocarditis. The aim was to examine the expression of ACE2 in normal hearts and hearts from patients with terminal heart failure. The ACE2 expression was measured by global quantitative proteomics and RT-qPCR in left ventricular (LV) tissue from explanted hearts. Immunohistochemistry was used to examine ACE2 expression in cardiomyocytes, fibroblasts and endothelial cells. In total, tissue from 14 organ donors and 11 patients with terminal heart failure were included. ACE2 expression was 2.6 times higher in 4 hearts from patients with terminal heart failure compared with 6 healthy donor hearts. The results were confirmed by immunohistochemistry where more than half of cardiomyocytes or fibroblasts showed expression of ACE2 in hearts from patients with terminal heart failure. In healthy donor hearts ACE2 was not expressed or found in few fibroblasts. A small subpopulation of endothelial cells expressed ACE2 in both groups. Upregulated ACE2 expression in cardiomyocytes may increase the risk of SARS-CoV-2 myocarditis in patients with heart failure.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Donantes de Tejidos / Miocitos Cardíacos / Células Endoteliales / Fibroblastos / Enzima Convertidora de Angiotensina 2 / Insuficiencia Cardíaca Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Donantes de Tejidos / Miocitos Cardíacos / Células Endoteliales / Fibroblastos / Enzima Convertidora de Angiotensina 2 / Insuficiencia Cardíaca Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido